JNJ-DGAT2-A,1962931-71-0

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JNJ-DGAT2-A

CAS No. : 1962931-71-0

MCE 国际站：JNJ-DGAT2-A

产品活性：JNJ-DGAT2-A 是一种选择性、剂量依赖的二酰基甘油酰基转移酶 2 (DGAT2) 抑制剂，在表达人 DGAT2 的 Sf9 昆虫细胞膜中 IC₅₀ 值为 0.14 μM。JNJ-DGAT2-A 可用于甘油三酯 (TG) 合成的研究。

研究领域：Metabolic Enzyme/Protease

作用靶点：Acyltransferase

In Vitro: JNJ-DGAT2-A (5 μM) inhibits about 99% of recombinant DGAT2 enzymatic activity.
JNJ-DGAT2-A (5 μM) inhibits the DGAT activity in HepG2 cell lysates.
JNJ-DGAT2-A (0.3125, 0.625, 1.25, 2.5, 5, 10, and 20 µM; 60 min prior to isotope-labeled and additional 2 h after isotope-labeled) dose-dependently inhibits the generation of TG (52:2), TG (54:3), and TG (50:2) using ¹³C3-D5-glycerol as a substrate in HepG2 cells with IC₅₀ values of 0.85 μM, 0.99 μM, and 0.66 μM, respectively.

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