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Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
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货期：1-2天
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10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥3300.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1363.0 |
| 规格： | 5 mg | 产品价格： | ￥3000.0 |
| 规格： | 10 mg | 产品价格： | ￥4500.0 |
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FPFT-2216
CAS No. : 2367619-87-0
MCE 国际站：FPFT-2216
产品活性：FPFT-2216 是一种“分子胶水”化合物，可降解磷酸二酯酶 6D (PDE6D)、锌指转录因子 Ikaros (IKZF1)、Aiolos (IKZF3) 和酪蛋白激酶 1α (CK1α)。FPFT-2216 可用于癌症和炎症疾病的研究。
研究领域：Metabolic Enzyme/Protease | Stem Cell/Wnt | Cell Cycle/DNA Damage | PROTAC
作用靶点：Phosphodiesterase (PDE) | Casein Kinase | Molecular Glues
In Vitro: FPFT-2216 (1 μM; 5 hours) is able to degrade PDE6D, in addition to its known targets IKZF1, IKZF3, and CK1α in MOLT4 cells.
?FPFT-2216 (1 μM; 0 h, 2 h, 4 h, 6 h, 16 h, 24 h) shows complete degradation of PDE6D within 2 h, and the degradation of PDE6D persists for at least 24 h in MOLT4 cells.
?FPFT-2216 (0 nM, 1.6 nM, 8 nM, 40 nM, 200 nM, 1 μM; 4 h) exhibits over 50% degradation of PDE6D at a dose of 8 nM, while maximum degradation of PDE6D along with IKZF1, IKZF3, and CK1α at a dose of 200 nM in MOLT4 cells.
?FPFT-2216 does not impede the growth of KRASG12C-dependent MIA PaCa-2 cells.
?FPFT-2216 (10, 20, 40 μM; 14 or 24 h) highly up-regulates the production of IL-2 although it is less potent than that of Pomalidomide in Naive CD4+ T cells.
?FPFT-2216 (10 μM; 14 or 24 h) degrades IKZF1 and CK-1α among ubiquitin–proteasomal degradative substrates of immunomodulatory drugs (IMiDs) in Naive CD4+ T cells.
In Vivo: FPFT-2216 (30 mg/kg; p.o. or i.p.) induces significant degradation of CK-1α, and IKZF1 in CRBNI391V mice.
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文献和实验,16236,17395, 19838,20286,22426,26933,32010,32257,37006 片段长度: 11497,5077,4749,4507,2838,2560,2459,2443,2140,1986,1700, 1159,1093,805,514,468,448,339,264,247,216,211,200,164, 150,94,87,72,15 PvuI
5.0g K2HPO4 2.5g 蒸馏水 1000ml 57、NA (Nutrient Agar) 牛肉膏 3.0g 蛋白胨 5.0g 琼脂 20.0g 蒸馏水 1000ml pH 6.6-7.0 58、甘露(糖)醇琼脂 (ATCC 1) 酵母膏 5.0g 蛋白胨 3.0g 甘露(糖)醇 25.0g 琼脂 15.0g 蒸馏水 1000ml 59、Marine琼脂 2216 (ATCC 2) 蛋白胨 5.0g 酵母膏 1.0g 柠檬酸铁 0.1g 溴化钾 0.08g NaCl 19.45g
57. NA （Nutrient Agar） 牛肉膏 3.0 g 蛋白胨 5.0 g 琼脂 20.0 g 蒸馏水 1000 ml pH 6.6-7.0 58. 甘露（糖）醇琼脂 （ATCC 1） 酵母膏 5.0 g 蛋白胨 3.0 g 甘露（糖）醇 25.0 g 琼脂 15.0 g 蒸馏水 1000 ml 59. Marine琼脂 2216 （ATCC
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