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4°C, protect from light
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货期：1-2天
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- CAS号：
81065-76-1
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5 mg/10 mg/50 mg/100 mg
| 规格： | 5 mg | 产品价格： | ￥375.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥600.0 |
| 规格： | 50 mg | 产品价格： | ￥2200.0 |
| 规格： | 100 mg | 产品价格： | ￥3400.0 |
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EUK-134
CAS No. : 81065-76-1
MCE 国际站：EUK-134
产品活性：EUK-134 是一种合成的超氧化物歧化酶和过氧化氢酶模拟物，可保护大鼠肾脏免受缺血再灌注引起的损伤。EUK-134 是一种具有过氧化氢酶活性的超氧化物歧化酶 (SOD) 模拟物 (SODm)。EUK-134 是一种保护有丝分裂的抗氧化剂。EUK-134 作用于 H9C2 细胞，降低 NF-κB 表达、MDA 水平和蛋白质羰基化。
研究领域：NF-κB
作用靶点：NF-κB
In Vitro: EUK-134 (10-300 μM) is able to improve cell viability and reduces Paraquat (1 mM)-induced cell death significantly via dismutation or scavenging of superoxide anions and reduces hydroxyl radical generation.
?Higher concentrations of EUK-134 alone (30-300 μM) produces modest but significant reductions in cellular viability; however, this effect is not reflected in cell death measurements made at these concentrations.
?EUK-134 is a salen-manganese complex with superoxide dismutase and catalase activity.Supplementation with EUK-134 is therefore identified as a novel approach to attenuate cardiac hypertrophy and lends scope for the development of EUK-134 as a therapeutic agent in the management of human cardiovascular disease.EUK-134 is a mitoprotective antioxidant with Mn-superoxide dismutase (Mn SOD) and catalase activity.
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文献和实验通过免疫组化的方法分析侵袭性乳腺癌中 GD2 表达的临床和病理相关性
隆抗体队整个肿瘤切片和组织微阵列做免疫组化，得到 GD2 的表达强度的结果，并分析其与临床病理特征和生存结果的相关性。 结果共有 134 例（占总数35%）乳腺癌组织是 GD2 阳性，中位 H 得分为 100。从抗 GD2 3F8 的染色结果看，染色位置主要在细胞质和核周，显示为颗粒状，并几乎全部染色出现在肿瘤区域。 研究团队发现：GD2 阳性与肿瘤组织学类型、低分级、雌激素受体阳性、低分期和多发性肿瘤显著相关。GD2 阳性和 GD2 阴性肿瘤患者的无事件生存率和总生存率无显著差异。研究团队得到的结果
或抑制的通道optoXR，给光激活后其改变的是胞内激酶系统，影响细胞活动。因此，光遗传学技术的核心技术差异在于光敏感通道的选择。 光遗传学的基本原理（Karl Deisseroth, et al., Annu. Rev. Biomed. Eng., 2014）常见的光敏感通道几种激活神经元的通道蛋白： ChR2(H134R)：470nm蓝光激发。ChR2的突变体，该蛋白质可以产生两倍的光电流，但通道开关速度也比野生的ChR2慢了一倍。 ChETA：470nm左右蓝光激发。ChR2的突变
an important role in regulation of the immune system. In the method described, hepatoma MH134 (Fas− and FasL− ) is transfected with murine Fas and FasL cDNA. A single administration of monoclonal anti-Fas antibody efficiently suppresses the growth of F6b (MH134
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