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货期：1-2天
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- CAS号：
1887237-54-8
- 规格：
10 mM * 1 mL/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥2244.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥2040.0 |
| 规格： | 10 mg | 产品价格： | ￥3080.0 |
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I-BET567
CAS No. : 1887237-54-8
MCE 国际站：I-BET567
产品活性：I-BET567 是一种有效、具有口服活性 pan-BET 候选抑制剂，对 BRD4 BD1 和 BD2 的 pIC50s 分别为 6.9 和 7.2。I-BET567 已在肿瘤和炎症小鼠模型中已被证明有效。
研究领域：Epigenetics
作用靶点：Epigenetic Reader Domain
In Vitro: I-BET567 (compound 27) (72 hours; 1.5 nM-30 μM) effectively inhibites the proliferation of human NMC cell line 11060 in vitro with a mean gpIC50 6.2 (0.63 μM).
In Vivo: I-BET567 (compound 27) (3, 10, and 30 mg/kg; p.o.; once daily for 20 days) leads to a significant reduction in tumor growth compared with vehicle controls at both 10 and 30 mg/kg.
Assessment of Pharmacokinetics (PK) profile of I-BET567 following intravenous infusion and oral administration in male wistar han rat and beagle doga.
| species | dose ivb/poc (mg/kg) | CLb (mL/min/kg) | CLb,u (mL/min/kg) | CLrenal (mL/min/kg) | Vss (L/kg) | Vss,u (L/kg) | t1/2 (h) | Fpo (%) | fub |
| rat | 1.3/3 | 25 | 109 | 7 | 2.4 | 10.4 | 1.6 | 99d | 0.23 |
| dog | 1.0/3 | 8.1 | 20 | 6.9 | 1.2 | 2.9 | 1.8 | 98 | 0.41 |
a: Values are mean, n=3 unless otherwise stated. b: IV dose 1h infusion in DMSO and (10%, w/v) Kleptose HPB in saline (2%: 98% (v/v)). c: PO dose vehicle: 1%(w/v) methycellulose (400 cps) (aq). d: Mean n = 2.
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文献和实验mapping tools. This may be your best bet if you simply need to locate some restriction sites to plan a cloning project. MAP allows you to search for any enzyme site in REBASE. MAPPLOT makes a graphical output from MAP. MAPSORT simulates a restriction
ml 854ml 783.7ml 711.7ml 639.8ml 567.2ml 494.3ml 420.7ml GuHCl %(w/w) 9.37 18.28 26.78 34.93 42.75 50.26 57.50 64.50 H2 O %(w/w) 90.63 81.72 73.22 65.07 57.25 49.74 42.50 35.50 p (g/ml) 1.020 1.045 1.070 1.094
Construction of Gene-Targeting Vectors by Recombineering
knockout (cko) targeting vectors using the pSim18 plasmid. This plasmid carries the three phage Red genes (Gam , Bet , and Exo ) under the control of the pL promoter, which is in turn regulated by the temperature-sensitive CI857 repressor
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