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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
TAC-101; Am 555S
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥936.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥446.0 |
| 规格： | 5 mg | 产品价格： | ￥1103.0 |
| 规格： | 10 mg | 产品价格： | ￥1788.0 |
| 规格： | 25 mg | 产品价格： | ￥2975.0 |
| 规格： | 50 mg | 产品价格： | ￥4325.0 |
| 规格： | 100 mg | 产品价格： | ￥5900.0 |
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Amsilarotene
CAS No. : 125973-56-0
MCE 国际站：Amsilarotene
产品活性：Amsilarotene (TAC-101; Am 555S) 是一种具有口服活性的合成类视黄醇，对视黄酸受体 α (RAR-α) 具有选择性亲和力，对 RAR-α 和 RAR-β 的 Ki 值为 2.4 nM 和 400 nM。Amsilarotene 诱导人胃癌、肝细胞癌和卵巢癌细胞的凋亡 (apoptotic)。Amsilarotene 可用于癌症研究。
研究领域：Metabolic Enzyme/Protease | Vitamin D Related/Nuclear Receptor | Apoptosis
In Vitro: Amsilarotene (0, 10, 25 μM; 24 hours) induces apoptosis of human epithelial ovarian carcinoma-derived cell lines in a concentration-dependent manner.
Amsilarotene (10, 20 μM; 0, 3, 6, and 9 days) inhibits the proliferation of BxPC-3 and MIAPaCa-2 cells.
Amsilarotene (10 μM; 48 hours) increases the proportion of sensitive BxPC-3 cells in the G1 phase.
Amsilarotene (10 μM; 0, 3, 6, 24, 48, 72 hours) inhibits the retinoblastoma-gene product (RB) phosphorylation in BxPC-3 cells between 24 and 72 hours.
In Vivo: Amsilarotene (8 mg/kg/day orally for 30 days) inhibits the RMG-II tumor growth in nude mice.
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