Pleckstrin homology domain-containing family O member 1
亚型:
Rabbit IgG
形态:
Liquid
保存条件:
4℃ for frequent use, -20℃ to -70℃ for 6 months
克隆性:
Polyclonal
标记物:
-
适应物种:
human, mouse
保质期:
-20℃ to -70℃ for 6 months
抗原来源:
详见说明书
目录编号:
P15005Rb
级别:
详见说明书
库存:
100
供应商:
伊艾博(武汉)EIAab
宿主:
Rabbit IgG
应用范围:
WB
浓度:
200ug/ml
靶点:
PLEKHO1
抗体英文名:
PLEKHO1 Antibody
抗体名:
PLEKHO1抗体
规格:
50ul/100ul/150ul/200ul
规格:
50ul
产品价格:
¥2750.0
规格:
100ul
产品价格:
¥4375.0
规格:
150ul
产品价格:
¥6250.0
规格:
200ul
产品价格:
¥6980.0
别名:PH domain-containing family O member 1,C-Jun-binding protein,JBP,Casein kinase 2-interacting protein 1,CK2-interacting protein 1,Osteoclast maturation-associated gene 120 protein,CKIP1,OC120,HQ0024c
序列号:Q53GL0
缓冲液:0.1M×PBS,50% glycerol,pH7.5
纯化方式:Immunogen affinity purified
通用注释 亚单元:Heterodimer or homodimer. Interacts with CK2 and actin capping subunits (capping protein CP-alpha and CP-beta). CKIP1 and CK2 together inhibit the activity of actin capping protein at the barbed ends of actin filaments. Interacts with ATM, IFP35, JUN, JUND, NMI and PI3K. Interacts with AKT1, AKT2 and AKT3 (each isozyme of PKB), PtdIns(3,5)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P2.
功能:Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
亚细胞位置: Cell membrane Peripheral membrane protein Nucleus Cytoplasm Predominantly localized to the plasma membrane through the binding to phosphatidylinositol 3-phosphate (PubMed:14729969). In C2C12 cells, with the absence of growth factor, it is found in the nucleus (PubMed:14729969). It rapidly translocates to the plasma membrane after insulin stimulation (PubMed:14729969). In response to TNF, it translocates from the plasma membrane to the cytoplasm and then to the nucleus accompanied by cleavage by caspase-3 (PubMed:15706351). However, the subcellular location is highly dependent of the cell type, and this explains why it is found exclusively at the plasma membrane, in some type of cells (Probable).