别名:JIP-4,Cancer/testis antigen 89,CT89,Human lung cancer oncogene 6 protein,HLC-6,JNK-associated leucine-zipper protein,JLP,Mitogen-activated protein kinase 8-interacting protein 4,Proliferation-inducing protein 6,Protein highly expressed in testis,PHET,Sperm surface protein,Sperm-associated antigen 9,Sperm-specific protein,Sunday driver 1,HSS,KIAA0516,MAPK8IP4,SYD1,HLC6
序列号:O60271
缓冲液:0.1M×PBS,50% glycerol,pH7.5
纯化方式:Immunogen affinity purified
通用注释 亚单元:Homodimer. The homodimer interacts with ARF6, forming a heterotetramer. Homooligomer. Interacts with MAX, MAPK8, MAPK9, MAPK10, MAPK14, MAP3K3, MYC, KNS2 and MAP2K4. Interaction with KNS2 is important in the formation of ternary complex with MAPK8. Interacts with NFKB1.
功能:The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg-interaction.
亚细胞位置: Isoform 5 Cytoplasmic vesicle Secretory vesicle Acrosome Associated with the plasma membrane of the acrosomal compartment and also localizes in the acrosome matrix.