别名:JFY-1,p53 up-regulated modulator of apoptosis,PUMA
序列号:Q9BXH1
研究领域:Apoptosis
缓冲液:0.1M×PBS,50% glycerol,pH7.5
纯化方式:Immunogen affinity purified
通用注释 亚单元:Interacts with MCL1 and BCL2A1 (By similarity). Interacts (via BH3 domain) with BCL2 (PubMed:11463391). Interacts with BCL2L1/BCL-XL (PubMed:23340338). Interacts (via BH3 domain) with NOL3/ARC (via CARD domain); this interaction prevents BBC3 association with BCL2 and results in CASP8 activation (By similarity).
功能:Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (PubMed:11463391). Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis (PubMed:23340338).
亚细胞位置: Mitochondrion Localized to the mitochondria in order to induce cytochrome c release.