储 存 液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
产品介绍:肝细胞分泌装置中极低密度脂蛋白 (VLDL) 的组装依赖于通过脂解和再酯化从细胞溶质池中调动三酰基甘油 (TAG)。然而,一些重新酯化的 TAG 产物会返回到肝脏中的细胞溶质池中,从而保护脆弱的身体组织免受血浆中过量的脂毒性非酯化脂肪酸的影响。参与该过程的一些脂肪酶包括芳基乙酰胺脱乙酰酶 (AADAC) 及其相关蛋白 AADACL1 和 AADACL2。 AADAC 是内质网的单通道 II 型膜蛋白,在肝细胞、肠黏膜细胞、胰腺和肾上腺中表达。它在芳胺底物对最终致癌物的代谢活化中起重要作用。 AADACL1 水解代谢中间体 2-乙酰基单烷基甘油,其失活导致癌细胞中醚脂质代谢的破坏和细胞迁移和肿瘤生长受损。
Function: Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionaly causes severe hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acids derived from hydrolysis of newly formed triglyceride stores.