别 名:Activin A receptor, type IC; Activin receptor like kinase 7; Activin receptor type 1C precursor; Activin receptor type IC; Activin receptor type-1C; Activin receptor-like kinase 7; ACTR IC; ACTR-IC; ACTRIC; ACV1C_HUMAN; Acvr1c; ACVRLK7; ALK 7; ALK-7; ALK7.
货号:YLK-KT0583
分 子 量:53kDa
细胞定位:细胞膜
纯化方法:affinity purified by Protein A
储 存 液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
产品介绍:在配体结合时形成受体复合物的丝氨酸/苏氨酸蛋白激酶。 受体复合物由 2 种 II 型和 2 种 I 型跨膜丝氨酸/苏氨酸激酶组成。 II 型受体磷酸化并激活 I 型受体,该受体自身磷酸化,然后结合并激活 SMAD 转录调节因子 SMAD2 和 SMAD3。 激活素 AB、激活素 B 和 NODAL 的受体。 在细胞分化、生长停滞和细胞凋亡中发挥作用。
Function: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.