别 名:Cyclic AMP response element binding protein 2; DNA binding protein TAXREB67; Activating Transcription Factor 4; ATF 4; ATF4 protein; CREB 2; CREB2; CREB-2; Cyclic AMP dependent transcription factor ATF 4; Tax Responsive Enhancer Element B67; TAXREB67; TXREB; ATF4_HUMAN.
货号:YLK-KT0461
分 子 量:38kDa
细胞定位:细胞核 细胞浆 细胞膜
纯化方法:affinity purified by Protein A
储 存 液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
产品介绍:该基因编码一种转录因子,该转录因子最初被鉴定为广泛表达的哺乳动物 DNA 结合蛋白,可以结合 HTLV-1 LTR 中的税收反应增强子元件。 编码的蛋白质也被分离并表征为 cAMP 反应元件结合蛋白 2 (CREB-2)。 该基因编码的蛋白质属于 DNA 结合蛋白家族,包括 AP-1 转录因子家族、cAMP 反应元件结合蛋白 (CREB) 和 CREB 样蛋白。 这些转录因子共享一个参与蛋白质-蛋白质相互作用的亮氨酸拉链区域,位于一段碱性氨基酸的 C 端,作为 DNA 结合域。 已经描述了编码相同蛋白质的两种替代转录物。 两个假基因位于 X 染色体 q28 处的一个区域中,该区域包含一个大的反向重复。
Function: Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production. It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4.