存储缓冲液:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:Cell Cycle
通用注释 亚单元:Homodimer; disulfide-linked (By similarity). Interacts with GFRAL; ligand of GFRAL which mediates GDF15 internalization and cellular signaling through interaction with RET (PubMed:28846098, PubMed:28846099).
功能:Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed:28953886, PubMed:28846097, PubMed:28846099, PubMed:28572090, PubMed:23468844, PubMed:29046435). On hepatocytes, inhibits growth hormone signaling (PubMed:28572090).
亚细胞位置: Secreted
文献
1. Growth Differentiation Factor 15 and Coronary Collateral Formation
Auth: Tao Sun, ; Yanbo Huang, ; M. Ian Phillips, ; Xinping Luo, ; Jun Zhu,Haiming Shi, ; Jian Li,