别名:ERO1-L-beta,Endoplasmic reticulum oxidoreductase beta,Endoplasmic reticulum oxidoreductin-1-like protein B,Oxidoreductin-1-L-beta,Ero1lb
序列号:Q8R2E9
来源:E.coli
种属:Mouse
标签:His
纯度:>9% by SDS-PAGE
浓度:Reconstitution Dependent
形态:Liquid
应用:ELISA、Western Blot、Antigen Protein
存储缓冲液:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:Store at -20°C. (Avoid repeated freezing and thawing.)
通用注释 亚单元:Homodimer; disulfide-linked (By similarity). Heterodimer with ERO1A; disulfide-linked (By similarity). Also detected as monomer. Homodimers may be somewhat less active than monomers. The abundance of monomers and homodimers may be tissue-specific. Interacts with P4HB (By similarity). Interacts with ERP44.
功能:Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2, PDIA3, PDIA4, PDIA6 and NXNDC12. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell (By similarity). Involved in oxidative proinsulin folding in pancreatic cells, hence required for glucose homeostasis in vivo.
亚细胞位置: Endoplasmic reticulum membrane Peripheral membrane protein Lumenal side The association with ERP44 may be essential for its retention in the endoplasmic reticulum.