Mouse Atr/ Serine/threonine-protein kinase ATR Protein
库存:
现货
供应商:
伊艾博(武汉)科技股份有限公司
CAS号:
-
规格:
50ug/100ug/200ug/0.5mg/1mg
规格:
50ug
产品价格:
¥6480
规格:
100ug
产品价格:
¥7480
规格:
200ug
产品价格:
¥8480
规格:
0.5mg
产品价格:
¥11480
规格:
1mg
产品价格:
¥17500
别名:Ataxia telangiectasia and Rad3-related protein,Kiaa4069
序列号:Q9JKK8
来源:E.coli
种属:Mouse
标签:His
序列:2313-2558aa
预估分子量:27.06 kDa (monomer)
纯度:>9% by SDS-PAGE
浓度:Reconstitution Dependent
研究领域:Cell Cycle
形态:Liquid
应用:ELISA、Western Blot、Antigen Protein
存储缓冲液:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:Cell Cycle
通用注释 亚单元:Forms a heterodimer with ATRIP. Binds to DNA, and to UV-damaged DNA with higher affinity. Interacts with RAD17, MSH2 and HDAC2. Present in a complex containing ATRIP and RPA-coated single-stranded DNA. Present in a complex containing CHD4 and HDAC2. Interacts with EEF1E1. This interaction is enhanced by UV irradiation. Interacts with CLSPN and CEP164 (By similarity). Interacts with TELO2 AND TTI1 (By similarity). Interacts with ATRIP (PubMed:20801936).
功能:Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates Ser-139 of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication (By similarity). Essential for preventing the occurrence of DNA damage during early embryogenesis.
亚细胞位置: Nucleus Chromosome Recruited to chromatin during S-phase. Redistributes to discrete nuclear foci upon DNA damage, hypoxia or replication fork stalling (By similarity).