别名:Ataxin-1 interacting ubiquitin-like protein,A1Up,Ataxin-1 ubiquitin-like-interacting protein A1U,Connexin43-interacting protein of 75 kDa,CIP75,C1orf6,CIP75,UBIN
序列号:Q9NRR5
来源:E.coli
种属:Human
标签:His
纯度:>9% by SDS-PAGE
浓度:Reconstitution Dependent
形态:Liquid
应用:ELISA、Western Blot、Antigen Protein
存储缓冲液:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:Store at -20°C. (Avoid repeated freezing and thawing.)
通用注释 亚单元:Homooligomer (Ref. 6). Binds signal sequences of proteins that are targeted to the endoplasmic reticulum. Interacts (via UBA domain) with GJA1 (not ubiquitinated) and with ubiquitin; both compete for the same binding site. Interacts (via UBA domain) with ubiquitin and with polyubiquitin chains. Interacts with PSMD2 (By similarity). Interacts (via ubiquitin-like domain) with PSMD4, a regulatory subunit of the 26S proteasome. Interacts with ATXN1/SCA1. Interaction with ATXN1 inhibits polyubiquitination of UBQLN4 and interferes with PSMD4 binding. Interacts with HERPUD1. Interacts (via ubiquitin-like domain) with UBQLN1 (via UBA domain). Interacts (via STI1 1 and 2 domains) with MAP1LC3A/B/C. Interacts with UBQLN2.
功能:Plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (Ref. 6). Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery. Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205).
亚细胞位置: Nucleus Cytoplasm Endoplasmic reticulum Cytoplasm Perinuclear region Cytoplasmic vesicle Autophagosome Colocalizes with the proteasome, both in nucleus and cytoplasm.