Human MAP1LC3A/ Microtubule-associated proteins 1A/1B light chain 3A Protein
库存:
现货
供应商:
伊艾博(武汉)科技股份有限公司
CAS号:
-
规格:
50ug/100ug/200ug/0.5mg/1mg
规格:
50ug
产品价格:
¥6480
规格:
100ug
产品价格:
¥7480
规格:
200ug
产品价格:
¥8480
规格:
0.5mg
产品价格:
¥11480
规格:
1mg
产品价格:
¥17500
别名:Autophagy-related protein LC3 A,Autophagy-related ubiquitin-like modifier LC3 A,MAP1 light chain 3-like protein 1,MAP1A/MAP1B light chain 3 A,MAP1A/MAP1B LC3 A,Microtubule-associated protein 1 light chain 3 alpha
序列号:Q9H492
来源:E.coli
种属:Human
标签:His
纯度:>9% by SDS-PAGE
浓度:Reconstitution Dependent
研究领域:Autophagy Pathway
形态:Liquid
应用:ELISA、Western Blot、Antigen Protein
存储缓冲液:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:Autophagy Pathway
通用注释 亚单元:3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity). Interacts with TP53INP1 and TP53INP2 (PubMed:19056683, PubMed:22470510). Directly interacts with SQSTM1; this interaction leads to MAP1LC3A recruitment to inclusion bodies containing polyubiquitinated protein aggregates and to inclusion body degradation by autophagy (PubMed:17580304). Interacts with ATG13 (PubMed:24290141, PubMed:23043107). Interacts with ULK1 (PubMed:23043107). Interacts with TBC1D5 (PubMed:22354992). Found in a complex with UBQLN1 and UBQLN2 (PubMed:20529957). Interacts with UBQLN4 (via STI1 1 and 2 domains). Interacts with UBQLN1 in the presence of UBQLN4 (PubMed:23459205). Interacts with TRIM5 (PubMed:25127057). Interacts with MEFV (PubMed:26347139). Interacts with FAM134A, FAM134B and FAM134C (PubMed:26040720).
功能:Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20713600, PubMed:24290141). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20713600).
亚细胞位置: Cytoplasm Cytoskeleton Endomembrane system Lipid-anchor Cytoplasmic vesicle Autophagosome membrane Lipid-anchor Cytoplasmic vesicle Autophagosome LC3-II binds to the autophagic membranes.