别名:IL-6,B-cell stimulatory factor 2,BSF-2,CTL differentiation factor,CDF,Hybridoma growth factor,Interferon beta-2,IFN-beta-2,IFNB2
序列号:P05231
来源:E.coli
种属:Human
标签:His
序列:30-212aa
预估分子量:20.13 kDa (monomer)
纯度:Greater than 95% by SDS-PAGE
浓度:Reconstitution Dependent
研究领域:Neurodegeneration
形态:Liquid
应用:ELISA、Western Blot、Antigen Protein
存储缓冲液:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:Neurodegeneration
通用注释
亚单元:N/A
功能:Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.
亚细胞位置: Secreted
文献
1. Inhibiting Rab27a in renal tubular epithelial cells attenuates the inflammation of diabetic kidney disease through the miR-26a-5p/CHAC1/NF-kB pathway
Auth: Ss Li, Yj Jia, M Xue, et al.
From: Life Sciences
2. Role of YAP-related T cell imbalance and epidermal keratinocyte dysfunction in the pathogenesis of atopic dermatitis
Auth: Jj Jia, Xm Mo, Fg Yan, et al.
From: Journal of Dermatological Science
3. Radiosensitivity of colorectal cancer and radiation-induced gut damages are regulated by gasdermin E
Auth: G Tan, Cj Lin, Cy Huang, et al.
From: Cancer Letters
4. Effect of high-dose rosuvastatin loading before percutaneous coronary intervention in female patients with non-ST-segment elevation acute coronary...
Auth: Y Gao, ZM Jia, YJ Sun, et al.
From: Chin Med J (Engl)
5. Egr-1 decreases adipocyte insulin sensitivity by tilting PI3K/Akt and MAPK signal balance in mice
Auth: Xiao Yu, Ning Shen, Ming-Liang Zhang,, Fei-Yan Pan, Chen Wang, Wei-Ping Jia, Chang Liu, Qian Gao, Xiang Gao, Bin Xue and Chao-Jun Li
From: The EMBO Journal
6. Preclinical efficacy of Dexmedetomidine on spinal cord injury provoked oxidative renal damage
Auth: Shou-Shi W, Ting-Ting S, Ji-Shun N, et al.
From: Renal failure
7. Promoter methylation status and expression of PPAR-γ gene are associated with prognosis of acute-on-chronic hepatitis B liver failure
Auth: Zhao Z H, Fan Y C, Zhao Q, et al.
From: Clinical epigenetics