Human C9orf72/ Guanine nucleotide exchange C9orf72 Protein
库存:
现货
供应商:
伊艾博(武汉)科技股份有限公司
CAS号:
-
规格:
50ug/100ug/200ug/0.5mg/1mg
规格:
50ug
产品价格:
¥6480
规格:
100ug
产品价格:
¥7480
规格:
200ug
产品价格:
¥8480
规格:
0.5mg
产品价格:
¥11480
规格:
1mg
产品价格:
¥17500
序列号:Q96LT7
来源:E.coli
种属:Human
标签:His
纯度:>9% by SDS-PAGE
浓度:Reconstitution Dependent
研究领域:Neurodegeneration
形态:Liquid
应用:ELISA、Western Blot、Antigen Protein
存储缓冲液:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:Neurodegeneration
通用注释 亚单元:Interacts with SMCR8; the interaction is direct (PubMed:27559131, PubMed:27617292). Component of the C9orf72-SMCR8 complex, at least composed of C9orf72, SMCR8 and WDR41 (PubMed:27193190, PubMed:27103069, PubMed:27559131, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex associates with the ATG1/ULK1 kinase complex (PubMed:27617292, PubMed:28195531). Interacts with ATG1/ULK1 kinase complex members ULK1, ATG13 and RB1CC1 (PubMed:27334615). Interacts with HNRNPA1, HNRNPA2B1 and UBQLN2 (PubMed:24549040). Interacts with small Rab GTPase RAB1A; the interaction mediates recruitment of RAB1A to the ATG1/ULK1 kinase complex (PubMed:27334615). Also interacts with small Rab GTPase RAB7A (By similarity). Interacts with cofilin (PubMed:27723745). Interacts with GTP-binding proteins ARF1 and ARF6 (By similarity).
功能:Isoform 2: Does not play a role in regulation of stress granule assembly in response to cellular stress.
亚细胞位置: Isoform 2 Nucleus membrane Peripheral membrane protein Nucleus Detected at the nuclear membrane of cerebellar Purkinje cells and spinal motor neurons. Also shows diffuse nuclear expression in spinal motor neurons.