Human COMP/ Cartilage oligomeric matrix protein Protein
库存:
现货
供应商:
伊艾博(武汉)科技股份有限公司
CAS号:
-
规格:
50ug/100ug/200ug/0.5mg/1mg
规格:
50ug
产品价格:
¥6480
规格:
100ug
产品价格:
¥7480
规格:
200ug
产品价格:
¥8480
规格:
0.5mg
产品价格:
¥11480
规格:
1mg
产品价格:
¥17500
别名:COMP,Thrombospondin-5,TSP5
序列号:P49747
来源:E.coli
种属:Human
标签:His
纯度:>9% by SDS-PAGE
浓度:Reconstitution Dependent
研究领域:Cell Cycle
形态:Liquid
应用:ELISA、Western Blot、Antigen Protein
存储缓冲液:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:Cell Cycle
通用注释 亚单元:Pentamer; disulfide-linked. Exists in a more compact conformation in the presence of calcium and shows a more extended conformation in the absence of calcium. Interacts with ITGB3, ITGA5 and FN1. Binding to FN1 requires the presence of divalent cations (Ca(2+), Mg(2+) or Mn(2+)). The greatest amount of binding is seen in the presence of Mn(2+). Interacts with MATN1, MATN3, MATN4 and ACAN. Binds heparin, heparan sulfate and chondroitin sulfate. EDTA dimishes significantly its binding to ACAN and abolishes its binding to MATN3, MATN4 and chondroitin sulfate. Interacts with collagen I, II and IX, and interaction with these collagens is dependent on the presence of zinc ions. Interacts with ADAMTS12. Interacts with ITGA7.
功能:May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7.
亚细胞位置: Secreted Extracellular space Extracellular matrix