别名:ASH-1,Class A basic helix-loop-helix protein 46,bHLHa46,ASH1,BHLHA46,HASH1
序列号:P50553
来源:E.coli
种属:Human
标签:His
序列:Recombinant protein
纯度:>9% by SDS-PAGE
浓度:Reconstitution Dependent
形态:Liquid
应用:ELISA、Western Blot、Antigen Protein
存储缓冲液:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:Store at -20°C. (Avoid repeated freezing and thawing.)
通用注释 亚单元:Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with TCF3.
功能:Transcription factor that controls transcriptional expression of its target genes by binding to the E box (5'-CANNTG-3'). Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Essential for the generation of olfactory and autonomic neurons.
亚细胞位置: Nucleus