别 名:Cell proliferation inducing protein 54; Cell proliferation-inducing gene 54 protein; KIAA0648; PDS5A; PDS5A_HUMAN; PIG54; SCC-112; Sister chromatid cohesion protein 112; Sister chromatid cohesion protein PDS5 homolog A.
货号:YLK-KT0383
分 子 量:147kDa
细胞定位:细胞核
纯化方法:affinity purified by Protein A
储 存 液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
产品介绍:有丝分裂中姐妹染色单体凝聚的可能调节剂,它可能稳定凝聚素复合物与染色质的结合。 可能将有丝分裂期间姐妹染色单体的凝聚力与 DNA 复制结合起来。 凝聚力确保染色体分配在减数分裂和有丝分裂细胞中都是准确的,并在 DNA 修复中发挥重要作用。
Function: Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Subunit: Interacts with the cohesin complex. Interacts with WAPAL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive. Interacts with SMC3. Interacts with TP63.
Subcellular Location: Nucleus. Associated with chromatin through most of the cell cycle. Dissociates from chromatin in late prophase, reassociates during late telophase.