- ￥815
- 翌圣生物（Yeasen）
- 90604ES08
- 上海
- 2026年02月12日
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- 详细信息
- 文献和实验
- 技术资料
- 保质期：
有效期1年
- 保存条件：
-20℃至-80℃保存
- 供应商：
翌圣生物科技(上海)股份有限公司
- 库存：
大量
- 英文名：
Recombinant Human B cell Activating Factor/TNFSF13B (Human BAFF/TNFSF13B)
- 规格：
5μg
Product Information
| Product Name |
Cat# |
Size |
Price（¥） |
| Recombinant Human B cell Activating Factor/TNFSF13B (Human BAFF/TNFSF13B) |
90604ES08 |
5μg |
815.00 |
| 90604ES60 |
100μg |
11125.00 |
|
| 90604ES76 |
500μg |
35395.00 |
Product Description
BAFF, a member of the TNF family, is a fundamental survival factor for transitional and mature B cells. Mature human BAFF consists of a 46 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 218 aa extracellular domain (ECD) with a stalk region and one TNF-like domain. Within aa 134-285 of the ECD, human BAFF shares 72% aa sequence identity with mouse BAFF. BAFF binds to three receptors, BAFF-R, transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI), and B cell maturation Ag (BCMA). BAFF receptors were strongly expressed in situ in primary central nervous system (CNS) lymphomas. In addition, BAFF costimulates T cell activation, promotes a Th1 biased immune response, and promotes the expansion of Treg cells. BAFF also promotes monocyte survival, proinflammatory cytokine secretion, and differentiation to macrophage.
Product Properties
| Synonyms |
BLyS, CD257, TNFSF13B, TNFSF20, TALL-1, BLys, THANK, BAFFB-cell activating factor, ZTNF4 |
| Accession |
|
| GeneID |
|
| Source |
E.coli-derived Human BAFF, Ala134-Leu285, with an N-terminal Met. |
| Molecular Weight |
Approximately 17.2 kDa. |
| AA Sequence |
MAVQGPEETV TQDCLQLIAD SETPTIQKGS YTFVPWLLSF KRGSALEEKE NKILVKETGY FFIYGQVLYT DKTYAMGHLI QRKKVHVFGD ELSLVTLFRC IQNMPETLPN NSCYSAGIAK LEEGDELQLA IPRENAQISL DGDVTFFGAL KLL |
| Tag |
None |
| Physical Appearance |
Sterile Filtered White lyophilized (freeze-dried) powder. |
| Purity |
>95% by SDS-PAGE and HPLC analyses. |
| Biological Activity |
The ED50 as determined by a mouse splenocyte survival assay is 0.5-2 µg/mL. Fully biologically active when compared to standard. |
| Endotoxin |
< 1.0 EU per 1μg of the protein by the LAL method. |
| Formulation |
Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.0. |
| Reconstitution |
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions. |
Shipping and Storage
The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.
Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
Cautions
Avoid repeated freeze-thaw cycles.
For your safety and health, please wear lab coats and disposable gloves for operation.
For research use only!
HB220215
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文献和实验上海西唐生物科技有限公司 021-55229872, 65333639 www.westang.com 人B 淋巴细胞刺激因子 (BAFF)ELISA 试剂盒 ( 用于血清、血浆、细胞培养上清液和其它生物体液内 ) 原理 本实验采用双抗体夹心 ABC-ELISA 法。用抗人 BAFF（ BAFF/BLyS/TNFSF13B ） 单抗包被于酶标板上，标准品和样品中的 BAFF
上海西唐生物科技有限公司 021-55229872, 65333639 www.westang.com 小鼠B 淋巴细胞刺激因子 (BAFF)ELISA 试剂盒 ( 用于血清、血浆、细胞培养上清液和其它生物体液内 ) 原理 本实验采用双抗体夹心 ABC-ELISA 法。用抗小鼠 BAFF（ BAFF/BLyS/TNFSF13B ） 单抗包被于酶标板上，标准品和样品
的作用是调控基因表达。例如组蛋白甲基化多导致基因沉默，去甲基化则相反；乙酰化一般是转录激活，去乙酰化则相反。当然，也可在此基础上产生复杂的生物学效应。例如组蛋白去乙酰化酶 HDAC 可影响免疫系统；H3K4me3、H3K9me2 能够调控记忆的形成, 而且 H3K 甲基化与 X 染色体失活、基因组印记和异染色质形成有关；H3 乙酰化通过多种机制调控以来 ATP 的染色质重塑 ，并参与炎症反应；H2A、H2B 泛素化则与 DNA 损害反应有关；而 H3S28 磷酸化与 H3K27 乙酰化可激活转录
