别 名:STAT1 (phospho Y701); p-STAT1 (phospho Y701); Phospho-Stat1(pTyr701); STAT1(Phospho-Tyr701); signal transducers and activators of transcription 1; DKFZp686B04100; ISGF 3; Phosphorylated Stat1(pTyr701); Signal transducer and activator of transcription 1 91kDa; Signal transducer and activator of transcription 1 alpha/beta; STAT 1; STAT 91; STAT91; Transcription factor ISGF 3 components p91 p84.
货号:YLK-KT0073
分 子 量:82kDa
细胞定位:细胞核 细胞浆
纯化方法:affinity purified by Protein A
储 存 液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
产品介绍:该基因编码的蛋白质是 STAT 蛋白家族的成员。 响应细胞因子和生长因子,STAT 家族成员被受体相关激酶磷酸化,然后形成同型或异型二聚体,转移到细胞核,在那里它们充当转录激活剂。 这种蛋白质可以被各种配体激活,包括干扰素-α、干扰素-γ、EGF、PDGF和IL6。 这种蛋白质介导多种基因的表达,这被认为对于响应不同细胞刺激和病原体的细胞活力很重要。 已经描述了两种编码不同同种型的选择性剪接转录变体。
Function: Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.