抗人CD45抗体(T29/33) [ICH1173]/Bul

关键词：Bulk anti-Human CD45 antibody (T29/33) [ICH1173]，抗人CD45抗体(T29/33) [ICH1173]，CD45 antibody (T29/33) [ICH1173]

产品名称：抗人CD45抗体(T29/33) [ICH1173]-Bulk anti-Human CD45 antibody (T29/33) [ICH1173]

产品货号：ICH1173

产品规格：5868/5mg#15264/25mg#25092/50mg#39276/100mg

背景资料：CD45 is a 180-240kD glycoprotein member of the protein tyrosine phosphatase (PTP) family known for its involvement in regulating a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 and its isoforms are vital regulators of T- and B-cell antigen receptor signaling. CD45 functions through its extracellular domain or through its cytoplasmic domain, and serves as a negative regulator of cytokine receptor signaling via JAK kinase supression. The large extracellular domain is highly glycosylated, and its multiple isoforms allow extensive variation in the structure of its side chains. CD45 isoforms show cell-type and differentiation-stage specific expression that can be used as markers that identify and distinguish between different types of immune cells. CD45R is an isoform of CD45 with a molecular weight of 220 kD. CD45R contains all three possible exons (A,B, and C); making it the longest protein generated from alternative splicing with a migration at 200 kD when isolated from T cells. Furthermore, B cells express CD45R with heavier glycosylation, bringing the molecular weight to 220 kD, hence the name B220. Notably, B220 expression is not only restricted to B cells and may also be expressed on activated T cells, on a subset of dendritic cells, and on other antigen-presenting cells. Additionally, activated and memory T lymphocytes express CD45RO which facilitates T cell activation. CD45RO lacks all three possible exons (A, B, and C), making it the shortest CD45 isoform.

保存建议：抗人CD45抗体(T29/33) [ICH1173]-Bulk anti-Human CD45 antibody (T29/33) [ICH1173]This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.

产品描述：Mouse

点击：抗人CD45抗体(T29/33) [ICH1173]-Bulk anti-Human CD45 antibody (T29/33) [ICH1173]查看更详细产品说明，更多应用、储存、价格、货期等信息请致电400-6800-868垂询Ichorbio中国区域授权总代理艾美捷科技有限公司。更多特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看艾美捷特色产品网站。

ichorbio成立于英国牛津，专注于为广大研究者提供体内研究用抗体和研究级生物仿制药抗体。产品线包括：1.体内抗体: 两种类型的抗小鼠体内抗体——低内毒素和超低内毒素；2.研究用生物仿制药: 仅用于研究用途（不用于诊断或治疗用途）；3.抗人的抗体：标准生产多规格（最多100毫克）的抗人抗体，并且每种抗体都有克数的库存。ichorbio提供的抗体包括两种系列：低内毒素（Low endotoxin）和超低内毒素（Ultra-low endotoxin），可以满足或超过任何研究机构体内工作所需的严格要求和严格标准。

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