HSC3/HSC3/HSC3/口腔鳞状肿瘤细胞

HSC3/HSC3细胞系/HSC3细胞株/HSC3口腔鳞状肿瘤细胞

Cell line name HSC-3

Synonyms HSC 3; HSC3

Accession CVCL_1288

Resource Identification Initiative To cite this cell line use: HSC-3 (RRID:CVCL_1288)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Population: Japanese.

Doubling time: 20.28 hours (PubMed=21362583); 20 hours (PubMed=24627082); ~60 hours (Note=Lot 121498), ~44 hours (Note=Lot 07242009), ~52 hours (Note=Lot 02022015), 42-65 hours (Note=Lot 07112016), ~37 hours (Note=Lot 06112018) (JCRB=JCRB0623).

Microsatellite instability: Stable (MSS) (Sanger).

Omics: Array-based CGH.

Omics: CRISPR phenotypic screen.

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Miscellaneous: STR profile from personal communication of Sano, Daisuke.

Derived from site: Metastatic; Cervical lymph node; UBERON=UBERON_0002429.

PubMed=17599052; DOI=10.1038/sj.onc.1210589

Suzuki E., Imoto I., Pimkhaokham A., Nakagawa T., Kamata N., Kozaki K.-i., Amagasa T., Inazawa J.

PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation.

Oncogene 26:7921-7932(2007)

 

PubMed=17719389; DOI=10.1016/j.joms.2006.11.034

Erdem N.F., Carlson E.R., Gerard D.A., Ichiki A.T.

Characterization of 3 oral squamous cell carcinoma cell lines with different invasion and/or metastatic potentials.

J. Oral Maxillofac. Surg. 65:1725-1733(2007)

 

PubMed=18097548; DOI=10.3892/ijo.32.1.101

Murugan A.K., Hong N.T., Fukui Y., Munirajan A.K., Tsuchida N.

Oncogenic mutations of the PIK3CA gene in head and neck squamous cell carcinomas.

Int. J. Oncol. 32:101-111(2008)

 

PubMed=18423281; DOI=10.1016/j.joms.2007.12.036

Erdem N.F., Carlson E.R., Gerard D.A.

Characterization of gene expression profiles of 3 different human oral squamous cell carcinoma cell lines with different invasion and metastatic capacities.

J. Oral Maxillofac. Surg. 66:918-927(2008)

 

PubMed=18973137; DOI=10.1002/gcc.20626

Sugimoto T., Seki N., Shimizu S., Kikkawa N., Tsukada J., Shimada H., Sasaki K., Hanazawa T., Okamoto Y., Hata A.

The galanin signaling cascade is a candidate pathway regulating oncogenesis in human squamous cell carcinoma.

Genes Chromosomes Cancer 48:132-142(2009)

 

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113

Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Signatures of mutation and selection in the cancer genome.

Nature 463:893-898(2010)

 

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662

Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Cancer Res. 70:2158-2164(2010)

 

PubMed=21362583; DOI=10.1016/j.anl.2011.01.018

Sakakibara A., Tsukuda M., Kondo N., Ishiguro Y., Kimura M., Fujita K., Takahashi H., Matsuda H.

Examination of the optimal condition on the in vitro sensitivity to telomelysin in head and neck cancer cell lines.

Auris Nasus Larynx 38:589-599(2011)