OS-RC-2/OS-RC-2/OS-RC-2/人肾细胞癌细

OS-RC-2/OS-RC-2细胞系/OS-RC-2细胞株/OS-RC-2人肾细胞癌细胞

Cell line name OS-RC-2

Synonyms OSRC2; RC-2

Accession CVCL_1626

Resource Identification Initiative To cite this cell line use: OS-RC-2 (RRID:CVCL_1626)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Population: Japanese.

Doubling time: ~60 hours (Note=At 30th passage) (PubMed=4008433).

Microsatellite instability: Stable (MSS) (Sanger).

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: In situ; Kidney; UBERON=UBERON_0002113.

Sequence variations

Mutation; HGNC; 9588; PTEN; Simple; p.Cys211Serfs (c.631_634+12del16); Zygosity=Heterozygous (Cosmic-CLP=909250; DepMap=ACH-000159).

Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=31068700).

Mutation; HGNC; 11998; TP53; None_reported; -; Zygosity=- (Cosmic-CLP=909250; DepMap=ACH-000159).

HLA typing Source: PubMed=26589293

Class I

HLA-A A*24:02,24:02

HLA-B B*52:01,52:01

HLA-C C*12:02,12:02

Genome ancestry Source: PubMed=30894373

 

Origin % genome

African 0.1

Native American 0

East Asian, North 77.03

East Asian, South 20.25

South Asian 0

European, North 0.95

European, South 1.66

Disease Clear cell renal cell carcinoma (NCIt: C4033)

Clear cell renal carcinoma (ORDO: Orphanet_319276)

Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell Male

Age at sampling 52Y

Category Cancer cell line

STR profile Source(s): CCRID; Cosmic-CLP=909250; RCB=RCB0735

 

Markers:

Amelogenin X,Y

CSF1PO 12,13

D2S1338 20

D3S1358 17

D5S818 11,12

D7S820 10,11

D8S1179 14

D13S317 8,12

D16S539 11

D18S51 14

D19S433 13,14

D21S11 31.2

FGA 24

TH01 6

TPOX 8,11

vWA 16

 

Run an STR similarity search on this cell line

Publications

PubMed=4008433; DOI=10.1007/BF02620929

Kinouchi T., Kotake T., Mori Y., Abe T.

Human renal cell carcinoma: establishment and characterization of a new cell line (OS-RC-2).

In Vitro Cell. Dev. Biol. 21:195-199(1985)

 

PubMed=14534724; DOI=10.3892/or.10.6.1947

Ikemoto S., Narita K., Yoshida N., Wada S., Kishimoto T., Sugimura K., Nakatani T.

Effects of tumor necrosis factor alpha in renal cell carcinoma.

Oncol. Rep. 10:1947-1955(2003)

 

PubMed=15604581; DOI=10.1159/000081597

Ikemoto S., Sugimura K., Yoshida N., Kuratsukuri K., Wada S., Nakatani T.

Comparative antitumor activity of 5-fluorouracil and 5'-deoxy-5-fluorouridine in combination with interferon-alpha in renal cell carcinoma cell lines.

Urol. Int. 73:348-353(2004)

 

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113

Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Signatures of mutation and selection in the cancer genome.

Nature 463:893-898(2010)

 

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878

Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Genome Med. 7:118.1-118.7(2015)

 

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469

Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., M, Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

A landscape of pharmacogenomic interactions in cancer.

Cell 166:740-754(2016)

 

PubMed=28489074; DOI=10.1038/ncomms15165; PMCID=PMC5436135

Sinha R., Winer A.G., Chevinsky M.S., Jakubowski C., Chen Y.-B., Dong Y.-Y., Tickoo S.K., Reuter V.E., Russo P., Coleman J.A., Sander C., Hsieh J.J.-D., Hakimi A.A.

Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection.

Nat. Commun. 8:15165.1-15165.10(2017)

 

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Cancer Res. 79:1263-1273(2019)