Hepa 1-6/Hepa 1-6/Hepa 1-6/小鼠肝

Hepa 1-6/Hepa 1-6细胞系/Hepa 1-6细胞株/Hepa 1-6小鼠肝癌细胞

Cell line name Hepa 1-6

Synonyms HEPA 1-6; Hepa-1-6; Hepa1-6

Accession CVCL_0327

Resource Identification Initiative To cite this cell line use: Hepa 1-6 (RRID:CVCL_0327)

Comments Doubling time: 26.99 +- 1.93 hours (PubMed=28152020); ~30 hours (DSMZ=ACC-175).

Omics: Deep phosphoproteome analysis.

Omics: Deep proteome analysis.

Omics: Transcriptome analysis by microarray.

Derived from site: In situ; Liver; UBERON=UBERON_0002107.

Disease Hepatocellular carcinoma of the mouse (NCIt: C38756)

Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)

Breed/subspecies: C57L.

Hierarchy Parent: CVCL_S550 (Hepa-1)

Children:

CVCL_IU28 (Dt81Hepa1-6) CVCL_C8Y7 (Hepa 1-6-Luc) CVCL_A5BH (Hepa 1-6/10R)

CVCL_RI52 (Hepa/8F5) CVCL_RA18 (Hepa1-6-eGFP-Puro) CVCL_RA19 (Hepa1-6-Fluc-Neo)

CVCL_RA20 (Hepa1-6-Fluc-Neo/eGFP-Puro) CVCL_RA21 (Hepa1-6-iRFP-Puro) CVCL_E1L8 (HyCyte Hepa 1-6 KO-mEno1)

CVCL_D6BL (HyCyte Hepa 1-6 KO-mSlc39a1) CVCL_E1L9 (HyCyte Hepa 1-6 KO-mTrp53) CVCL_B6ZC (Res1-6)

CVCL_E0V9 (Ubigene Hepa 1-6 Bcl9 KO) CVCL_E0VA (Ubigene Hepa 1-6 C3 KO) CVCL_E0VB (Ubigene Hepa 1-6 Clec10a KO)

CVCL_E0VC (Ubigene Hepa 1-6 Hif1a KO) CVCL_E0VD (Ubigene Hepa 1-6 Mettl4 KO)

Sex of cell Female

Category Cancer cell line

STR profile Source(s): PubMed=31220119; Ubigene=YC-A005

 

Markers:

Mouse STR 1-1 14,15,16

Mouse STR 1-2 13

Mouse STR 2-1 14

Mouse STR 3-2 10

Mouse STR 4-2 18.3,19.3

Mouse STR 5-5 17

Mouse STR 6-4 18,19

Mouse STR 6-7 15

Mouse STR 7-1 25.2

Mouse STR 8-1 15

Mouse STR 11-2 16

Mouse STR 12-1 17

Mouse STR 13-1 17.1

Mouse STR 15-3 17,18,19

Mouse STR 17-2 14

Mouse STR 18-3 16,17

Mouse STR 19-2 10,11

Mouse STR X-1 25

 

Run an STR similarity search on this cell line

Publications

PubMed=11004682; DOI=10.1002/1097-0215(20001015)88:2<287::AID-IJC22>3.0.CO;2-U

Briz O., Serrano M.A., Macias R.I.R., Marin J.J.G.

Overcoming cisplatin resistance in vitro by a free and liposome-encapsulated bile acid derivative: BAMET-R2.

Int. J. Cancer 88:287-292(2000)

 

PubMed=12606785; DOI=10.1124/mol.63.3.742

Briz O., Macias R.I.R., Vallejo M., Silva A., Serrano M.A., Marin J.J.G.

Usefulness of liposomes loaded with cytostatic bile acid derivatives to circumvent chemotherapy resistance of enterohepatic tumors.

Mol. Pharmacol. 63:742-750(2003)

 

PubMed=25193168; DOI=10.1074/mcp.M113.037291; PMCID=PMC4256493

Hornburg D., Drepper C., Butter F., Meissner F., Sendtner M., Mann M.

Deep proteomic evaluation of primary and cell line motoneuron disease models delineates major differences in neuronal characteristics.

Mol. Cell. Proteomics 13:3410-3420(2014)

 

PubMed=26280412; DOI=10.1038/nbt.3327

Humphrey S.J., Azimifar S.B., Mann M.

High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics.

Nat. Biotechnol. 33:990-995(2015)

 

PubMed=28152020; DOI=10.1371/journal.pone.0171215; PMCID=PMC5289561

Lacoste B., Raymond V.-A., Cassim S., Lapierre P., Bilodeau M.

Highly tumorigenic hepatocellular carcinoma cell line with cancer stem cell-like properties.

PLoS ONE 12:E0171215-E0171215(2017)

 

PubMed=31220119; DOI=10.1371/journal.pone.0218412; PMCID=PMC6586308

Almeida J.L., Dakic A., Kindig K., Kone M., Letham D.L.D., Langdon S., Peat R., Holding-Pillai J., Hall E.M., Ladd M., Shaffer M.D., Berg H., Li J.-L., Wigger G., Lund S., Steffen C.R., Fransway B.B., Geraghty B., Natoli M., Bauer B.A., Gollin S.M., Lewis D.W., Reid Y.A.

Interlaboratory study to validate a STR profiling method for intraspecies identification of mouse cell lines.

PLoS ONE 14:E0218412-E0218412(2019)