Daoy/Daoy/Daoy/人脑髓母细胞瘤细胞

Daoy/Daoy细胞系/Daoy细胞株/Daoy人脑髓母细胞瘤细胞

Cell line name Daoy

Synonyms DAOY; D324 Med; D-324 Med; D324 MED; D-324MED; D324

Accession CVCL_1167

Secondary accession CVCL_7903

Resource Identification Initiative To cite this cell line use: Daoy (RRID:CVCL_1167)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Population: Caucasian.

Doubling time: 33.6 hours (Note=At 48th passage) (PubMed=2993532); 32 +- 1.5 hours (PubMed=31346954); 34 hours (ATCC=HTB-186).

Microsatellite instability: Stable (MSS) (Sanger).

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: Proteome analysis by 2D-DE/MS.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: In situ; Brain, posterior fossa; UBERON=UBERON_0008788.

PubMed=18773455; DOI=10.1002/cyto.a.20633

Srivastava V.K., Nalbantoglu J.

Flow cytometric characterization of the DAOY medulloblastoma cell line for the cancer stem-like phenotype.

Cytometry A 73:940-948(2008)

 

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113

Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Signatures of mutation and selection in the cancer genome.

Nature 463:893-898(2010)

 

PubMed=20847082; DOI=10.1093/neuonc/noq091; PMCID=PMC3018940

Teider N., Scott D.K., Neiss A., Weeraratne S.D., Amani V.M., Wang Y.-F., Marquez V.E., Cho Y.-J., Pomeroy S.L.

Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma.

Neuro-oncol. 12:1244-1256(2010)

 

PubMed=22343310; DOI=10.1016/j.neulet.2012.02.022

Ghassemifar S., Mendrysa S.M.

MDM2 antagonism by nutlin-3 induces death in human medulloblastoma cells.

Neurosci. Lett. 513:106-110(2012)

 

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027

Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Nature 483:603-607(2012)

 

PubMed=22723427; DOI=10.1093/neuonc/nos130; PMCID=PMC3424207

Sikkema A.H., den Dunnen W.F.A., Hulleman E., van Vuurden D.G., Garcia-Manero G., Yang H., Scherpen F.J.G., Kampen K.R., Hoving E.W., Kamps W.A., Diks S.H., Peppelenbosch M.P., de Bont E.S.J.M.

EphB2 activity plays a pivotal role in pediatric medulloblastoma cell adhesion and invasion.

Neuro-oncol. 14:1125-1135(2012)

 

PubMed=24297863; DOI=10.1158/1078-0432.CCR-13-2281; PMCID=PMC4198154

Bandopadhayay P., Bergthold G., Nguyen B., Schubert S., Gholamin S., Tang Y.-J., Bolin S., Schumacher S.E., Zeid R., Masoud S., Yu F.-R., Vue N., Gibson W.J., Paolella B.R., Mitra S.S., Cheshier S.H., Qi J., Liu K.-W., Wechsler-Reya R.J., Weiss W.A., Swartling F.J., Kieran M.W., Bradner J.E., Beroukhim R., Cho Y.-J.

BET bromodomain inhibition of MYC-amplified medulloblastoma.

Clin. Cancer Res. 20:912-925(2014)

 

PubMed=25877200; DOI=10.1038/nature14397

Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.

A resource for cell line authentication, annotation and quality control.

Nature 520:307-311(2015)

 

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469

Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Miroo T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

A landscape of pharmacogenomic interactions in cancer.

Cell 166:740-754(2016)

 

PubMed=27498314; DOI=10.1016/j.jbiotec.2016.07.028

Ivanov D.P., Coyle B., Walker D.A., Grabowska A.M.

In vitro models of medulloblastoma: choosing the right tool for the job.

J. Biotechnol. 236:10-25(2016)

 

PubMed=27812533; DOI=10.1016/j.dib.2016.10.004; PMCID=PMC5079239

Ivanov D.P., Walker D.A., Coyle B., Grabowska A.M.

Data on the number and frequency of scientific literature citations for established medulloblastoma cell lines.

Data Brief 9:696-698(2016)