MV-4-11/MV-4-11/MV-4-11/慢性骨髓单核

MV-4-11/MV-4-11细胞系/MV-4-11细胞株/MV-4-11慢性骨髓单核细胞性白血病

Cell line name MV4-11

Synonyms MV-4-11; MV-4:11; MV4:11; MV 4;11; MV4;11; MV411; MV(4;11); MV4II

Accession CVCL_0064

Resource Identification Initiative To cite this cell line use: MV4-11 (RRID:CVCL_0064)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-9591.

Population: Caucasian.

Characteristics: CSF2 and IL3 dependent.

Doubling time: 32 hours (PubMed=25984343); ~48 hours (CLS=300295); ~50 hours (DSMZ=ACC-102).

Karyotypic information: 48,XY,t(4;11)(q21;q23),+8,+19 (ATCC=CRL-9591).

Microsatellite instability: Stable (MSS) (Sanger).

Omics: Acetylation analysis by proteomics.

Omics: Deep exome analysis.

Omics: Deep quantitative phosphoproteome analysis.

Omics: DNA methylation analysis.

Omics: shRNA library screening.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.

PubMed=12529668; DOI=10.1038/sj.leu.2402740

Quentmeier H., Reinhardt J., Zaborski M., Drexler H.G.

FLT3 mutations in acute myeloid leukemia cell lines.

Leukemia 17:120-124(2003)

 

PubMed=14504097; DOI=10.1182/blood-2003-02-0418

Taketani T., Taki T., Sugita K., Furuichi Y., Ishii E., Hanada R., Tsuchida M., Sugita K., Ida K., Hayashi Y.

FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy.

Blood 103:1085-1088(2004)

 

PubMed=14671638; DOI=10.1038/sj.leu.2403236

Drexler H.G., Quentmeier H., MacLeod R.A.F.

Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations.

Leukemia 18:227-232(2004)

 

PubMed=15843827; DOI=10.1038/sj.leu.2403749

Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J., Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M., Fioretos T.

Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.

Leukemia 19:1042-1050(2005)

 

PubMed=16408098; DOI=10.1038/sj.leu.2404081

Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.

JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.

Leukemia 20:471-476(2006)

 

PubMed=19608861; DOI=10.1126/science.1175371

Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.

Lysine acetylation targets protein complexes and co-regulates major cellular functions.

Science 325:834-840(2009)

 

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662

Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Cancer Res. 70:2158-2164(2010)

 

PubMed=20922763; DOI=10.1002/pbc.22801; PMCID=PMC3005554

Kang M.H., Smith M.A., Morton C.L., Keshelava N., Houghton P.J., Reynolds C.P.

National Cancer Institute pediatric preclinical testing program: model description for in vitro cytotoxicity testing.

Pediatr. Blood Cancer 56:239-249(2011)

 

PubMed=21552520; DOI=10.1371/journal.pone.0019169; PMCID=PMC3084268

Gu T.-L., Nardone J., Wang Y., Loriaux M., Villen J., Beausoleil S.A., Tucker M., Kornhauser J.M., Ren J.-M., MacNeill J., Gygi S.P., Druker B.J., Heinrich M.C., Rush J., Polakiewicz R.D.

Survey of activated FLT3 signaling in leukemia.

PLoS ONE 6:E19169-E19169(2011)