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- 详细信息
- 文献和实验
- 技术资料
- 英文名：
4T1
- 库存：
1x10^6/瓶/支
- 供应商：
上海酶研
- 肿瘤类型：
详询
- 细胞类型：
小鼠乳腺癌细胞
- ATCC Number：
详询
- 品系：
4T1
- 组织来源：
小鼠乳腺癌细胞
- 相关疾病：
4T1
- 物种来源：
哺乳动物
- 免疫类型：
详询
- 细胞形态：
贴壁/悬浮
- 是否是肿瘤细胞：
否
- 器官来源：
小鼠乳腺癌细胞
- 运输方式：
顺丰快递
- 年限：
5年
- 生长状态：
生长良好
4T1/4T1细胞系/4T1细胞株/4T1小鼠乳腺癌细胞
Cell line name 4T1
Synonyms 4T1-A; 4T1.0; 4T1/WT
Accession CVCL_0125
Resource Identification Initiative To cite this cell line use: 4T1 (RRID:CVCL_0125)
Comments Characteristics: Metastatic.
Characteristics: Widely used model in cancer research due to its high similarity to human breast cancer. The tumor growth and metastatic spread of 4T1 cells closely mimic the behavior of human breast cancer. The 4T1 cell line is considered an animal model for stage IV human breast cancer, as it is able to spontaneously metastasize in both post-operative and non-surgical models (CLS=300300).
Doubling time: 12.6 hours (ATCC=CRL-2539).
Selected for resistance to: ChEBI; CHEBI:9555; Tioguanine (6-thioguanine; 6-TG).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911.
Disease Malignant neoplasms of the mouse mammary gland (NCIt: C21678)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: BALB/cfC3H.
PubMed=10411109; DOI=10.1023/A:1006689719505
Lelekakis M., Moseley J.M., Martin T.J., Hards D., Williams E.D., Ho P., Lowen D., Javni J., Miller F.R., Slavin J., Anderson R.L.
A novel orthotopic model of breast cancer metastasis to bone.
Clin. Exp. Metastasis 17:163-170(1999)
PubMed=26857856; DOI=10.1007/s13577-015-0127-1
Abe H., Wada H., Baghdadi M., Nakanishi S., Usui Y., Tsuchikawa T., Shichinohe T., Hirano S., Seino K.-i.
Identification of a highly immunogenic mouse breast cancer sub cell line, 4T1-S.
Hum. Cell 29:58-66(2016)
PubMed=27177471; DOI=10.1016/j.canlet.2016.05.005
Sasaki S.-i., Baba T., Nishimura T., Hayakawa Y., Hashimoto S.-i., Gotoh N., Mukaida N.
Essential roles of the interaction between cancer cell-derived chemokine, CCL4, and intra-bone CCR5-expressing fibroblasts in breast cancer bone metastasis.
Cancer Lett. 378:23-32(2016)
PubMed=31220119; DOI=10.1371/journal.pone.0218412; PMCID=PMC6586308
Almeida J.L., Dakic A., Kindig K., Kone M., Letham D.L.D., Langdon S., Peat R., Holding-Pillai J., Hall E.M., Ladd M., Shaffer M.D., Berg H., Li J.-L., Wigger G., Lund S., Steffen C.R., Fransway B.B., Geraghty B., Natoli M., Bauer B.A., Gollin S.M., Lewis D.W., Reid Y.A.
Interlaboratory study to validate a STR profiling method for intraspecies identification of mouse cell lines.
PLoS ONE 14:E0218412-E0218412(2019)
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文献和实验*发表【中文论文】请标注：由上海酶研生物科技有限公司提供；
*发表【英文论文】请标注：From Shanghai EK-Bioscience Biotechnology Co., Ltd.
技术资料