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- 详细信息
- 文献和实验
- 技术资料
- 英文名:
INS-1
- 库存:
1x10^6/瓶/支
- 供应商:
上海酶研
- 肿瘤类型:
详询
- 细胞类型:
大鼠胰岛细胞瘤细胞
- ATCC Number:
详询
- 品系:
INS-1
- 组织来源:
大鼠胰岛细胞瘤细胞
- 相关疾病:
INS-1
- 物种来源:
哺乳动物
- 免疫类型:
详询
- 细胞形态:
贴壁/悬浮
- 是否是肿瘤细胞:
详询
- 器官来源:
大鼠胰岛细胞瘤细胞
- 运输方式:
顺丰快递
- 年限:
5年
- 生长状态:
生长良好
INS-1/INS-1细胞系/INS-1细胞株/INS-1大鼠胰岛细胞瘤细胞
Cell line name INS-1
Synonyms INS1
Accession CVCL_0352
Resource Identification Initiative To cite this cell line use: INS-1 (RRID:CVCL_0352)
Comments Characteristics: Established from the transplantable insulinoma RIN.
Transformant: NCIt; C17262; X-Ray.
Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
Cell type: Pancreatic beta cell; CL=CL_0000169.
Disease Rat insulinoma (NCIt: C121566)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: NEDH; RS=RS:0000603.
Hierarchy Children:
CVCL_WH61 (GRINCH) CVCL_E1LG (HyCyte INS-1 KO-rHnf1a) CVCL_E1LH (HyCyte INS-1 KO-rHnf4a)
CVCL_E1LI (HyCyte INS-1 KO-rIer3ip1) CVCL_E1LJ (HyCyte INS-1 KO-rSsr1) CVCL_EG57 (INS-1 832/1)
CVCL_7226 (INS-1 832/13) CVCL_EG56 (INS-1 832/2) CVCL_ZL55 (INS-1 832/3)
CVCL_2G79 (INS-1 833/117) CVCL_2G78 (INS-1 833/15) CVCL_2G77 (INS-1 834/40)
CVCL_0351 (INS-1E) CVCL_W945 (INS-r3)
Originate from same individual CVCL_J993 ! INS-2
CVCL_3584 ! RIN-m
CVCL_D163 ! RIN-r
Sex of cell Male
Age at sampling 666D
Category Cancer cell line
Publications
PubMed=1370150; DOI=10.1210/endo.130.1.1370150
Asfari M., Janjic D., Meda P., Li G.-D., Halban P.A., Wollheim C.B.
Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.
Endocrinology 130:167-178(1992)
PubMed=8697299
Poitout V., Olson L.K., Robertson R.P.
Insulin-secreting cell lines: classification, characteristics and potential applications.
Diabetes Metab. 22:7-14(1996)
PubMed=22538498; DOI=10.1159/000338793
Grozinsky-Glasberg S., Shimon I., Rubinfeld H.
The role of cell lines in the study of neuroendocrine tumors.
Neuroendocrinology 96:173-187(2012)
PubMed=36180704; DOI=10.1007/978-1-0716-2593-4_35
Zibolka J., Bahr I., Peschke E., Muhlbauer E., Bazwinsky-Wutschke I.
Human and rodent cell lines as models of functional melatonin-responsive pancreatic islet cells.
Methods Mol. Biol. 2550:329-352(2022)
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文献和实验*发表【中文论文】请标注:由上海酶研生物科技有限公司提供;
*发表【英文论文】请标注:From Shanghai EK-Bioscience Biotechnology Co., Ltd.
【on-target2.0】AAV感染胰腺 | 血清型·启动子·注射用量 | 一篇就GO了!
-PANX 和元生物通过自主创建的AAVneO®全新AAV血清型发现平台,开发了一种具有自主知识产权的新型AAV血清型——AAV-PANX。该血清型表现出高度的胰腺亲嗜性,通过腹腔注射即可实现高效转导胰腺,对于较难感染的胰岛细胞也表现出良好的转导效率。 图2 AAV-PANX高效转导胰腺 (内部测试,腹腔注射,2E+11 vg/只) 图3 AAV-PANX配合Ins2启动子精准高效靶向胰岛β细胞 (内部测试,腹腔注射,5E+11 vg
; CDP-DG, CDP-diacylglycerol; Ins, Inositol. For phosphoinositols, abbreviations are in the form Ins( x,y,z )P n , where x, y , and z refer to the positions of the phosphate groups on the myo-inositol ring and n refers to the total number of phosphates
: phosphatidylinositol; PtdIns4P. phosphatidylinositol 4-phosphate; PtdIns(4,5)P 2 phosphatidylinositol 4,5-bisphosphate; DG: diacylglycerol; PtdOH: phosphatidic acid; CDP-DG: CDP-diacylglycerol; Ins: Inositol. For phosphoinositols, abbreviations are in the form Ins( x,y
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