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- PeproTech
- 120-53
- 美国
- 2025年08月28日
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
PeproTech(派普泰克)
- 库存：
大量
- 英文名：
Recombinant Human sFRP-5
- 规格：
10ug/ 50ug /100ug /250ug /500ug /1mg
Recombinant Human sFRP-5
产品详情
产品编号：120-53产品描述：
Secreted Frizzled Related Proteins (sFRPs) are a family of glycosylated Wnt antagonists that inhibit Wnt signaling, either by directly binding to Wnt proteins to prevent their binding to Frizzled (Fz) family receptor proteins or by forming non‐functional interactions with Frizzled receptors. sFRPs share homology with the cysteine‐rich, extracellular domain of Frizzled proteins. sFRP‐5 is secreted in a variety of embryonic and adult tissues. During embryonic development, sFRP‐5 regulates formation of the retina, brain, trunk, foregut, anterior visceral endoderm, and epithelial structures through Wnt and BMP inhibition. In adults, sFRP‐5 is expressed by adipocytes, particularly in white adipose tissue, and acts as an anti‐inflammatory adipokine. Shown to improve metabolic function and reduce adipose tissue inflammation, sFRP‐5 also acts in a cardio‐protective manner after ischemia and reperfusion injury in the heart, suppressing the non‐canonical Wnt5a/JNK signaling pathway in macrophages and myocytes. sFRP‐5 levels are negatively correlated with obesity‐related disorders including insulin resistance, type 2 diabetes, dyslipidemia, atherosclerosis, and coronary artery disease. Downregulation by promoter hypermethylation is observed in numerous cancers including gastric, cervical, hepatocellular carcinoma, pancreatic, oral squamous cell, breast, colon, bladder, and renal. sFRP‐5 inhibits melanogenesis when expressed in vitiligo melanocytes. PeproTech's CHO cell‐derived Recombinant Human sFRP5 is a 288‐amino‐acid length glycoprotein with a calculated molecular weight of 32.7 kDa; however, due to glycosylation, protein migration occurs at an apparent molecular weight of approximately 33‐35 kDa by SDS‐PAGE analysis under both reducing and non‐reducing conditions.
Source:CHO cells
Synonyms:Secreted frizzled‐related protein 5, Frizzled‐related protein 1b, FRP‐1b, Secreted apoptosis‐related protein 3, SARP‐3
Calculated Molecular Weight:32.7 kDa
Accession Number:Q5T4F7
Gene ID:6425
Country Of Origin: USANot for human use.
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文献和实验我们知道，PeproTech的所有细胞因子和蛋白均为冻干粉，这使得运输非常便捷，只要常温即可。而且，细胞因子和蛋白冻干粉非常稳定，在-20℃或-80℃条件下可保存数年。冻干粉在使用前需进行溶解，然后以液体形式加到培养体系或注射入动物体内。溶解步骤非常关键，因溶解不好会导致细胞因子或蛋白的失活，这也是很多用户在实际使用中经常遇到的问题。 那么，应该如何进行正确的溶解呢？ 下面我们以Recombinant Human IL-4 (重组人IL-4，产品编号：200-04)的说明书为例
大家知道，PeproTech的所有细胞因子和蛋白均为冻干粉，这使得运输非常便捷，只要常温即可。而且，细胞因子和蛋白冻干粉非常稳定，在-20o C或-80o C条件下可保存数年。冻干粉在使用前需进行溶解，然后以液体形式加到培养体系或注射入动物体内。溶解步骤非常关键，因溶解不好会导致细胞因子或蛋白的失活，这也是很多用户在实际使用中经常遇到的问题。 应该如何进行正确的溶解呢？ 下面我们以Recombinant Human IL-4 (重组人IL-4，产品编号：200-04
活性的减弱。 3) 一定不能振荡(vortex)。 这里所说的振荡是指用涡旋仪进行快速振荡。 有用户会问，若想保证溶解液与冻干粉充分混匀，以实现细胞因子或重组蛋白的完全溶解，该怎么办呢? 答：多数细胞因子或重组蛋白的冻干粉是非常容易溶解的，一般我们用移液枪的枪头轻吹几下，即可使细胞因子或重组蛋白完全溶解。 对于不易溶解的细胞因子或蛋白，PeproTech会在说明书中进行备注(Note)。如在重组人IL-13(产品编号：200-13)的说明书中
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