Atpenin A5,119509-24-9

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Atpenin A5

CAS No. : 119509-24-9

MCE 国际站：Atpenin A5

产品活性：Atpenin A5 是一种有效且高度特异性的 complex II 抑制剂，IC₅₀ 为 ~10 nM，且是一种有效的 mK_ATP 通道激动剂和心脏保护剂。

研究领域：Membrane Transporter/Ion Channel

作用靶点：Potassium Channel

In Vitro: Atpenin A5 shows the inhibition profile for submitochondrial particles (SMPs), mitochondria, and cardiomyocytes, with IC50 values of 8.3, 9.3, and 8.5 nM, respectively. Atpenin A5 (AA5) is a potent and specific complex II inhibitor. Atpenin A5 (1 nM) also activates the mKATP channel and protects against simulated ischemia-reperfusion (IR) injury in isolated cardiomyocytes.

In Vivo: Atpenin A5 is a potent inhibitor of succinate dehydrogenase (SDH). Succinate dehydrogenase inhibition by Atpenin A5 promotes cardiomyocyte mitosis and regeneration in the postnatal heart after myocardial infarction (MI). Atpenin A5-injected mice demonstrated myocardial thickness at the infarct zone and a significant reduction in scar size compared with controls.

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