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- MedChemExpress(MCE)
- 美国
- HY-113439
- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Solution, -20°C, 2 years
- 库存：
货期：询盘
- 供应商：
MedChemExpress LLC
- CAS号：
71030-37-0
- 规格：
50 μg (312.04 μM * 0.5 mL in Ethanol)/100 μg (312.04 μM * 1 mL in Ethanol)
| 规格： | 50 μg (312.04 μM * 0.5 mL in Ethanol) | 产品价格： | ￥3300.0 |
|---|---|---|---|
| 规格： | 100 μg (312.04 μM * 1 mL in Ethanol) | 产品价格： | ￥5400.0 |
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12-HETE
CAS No. : 71030-37-0
MCE 国际站：12-HETE
产品活性：12-HETE 是花生四烯酸在 12-LOX 催化下的主要代谢产物，抑制细胞凋亡。12-HETE 通过整合素连接激酶 (ILK) 通路促进 NF-κB 的活化和核转位。12-HETE 具有抗血栓形成和促血栓形成作用。12-HETE 还是一种神经调节剂。
研究领域：Apoptosis
作用靶点：Apoptosis
In Vitro: 12-HETE participates in the inhibition of cell apoptosis by activating the ILK/NF-κB pathway, implying an important underlying mechanism that promotes the survival of ovarian cancer cells. 12-HETE facilitates cell survival by activating the integrin-linked kinase/NF-κB pathway in ovarian cancer. 12-HETE protects against cell apoptosis in ovarian cancer cells in a concentration-dependent manner. 12-HETE (1 µM) significantly decreases the activation of caspase-3 induced by serum deprivation (SD).12-HETE represses the increased activity of caspase-3 induced by SD in a concentration-dependent manner, with an IC50 value of 1.13 µM.
12-HETE (1 µM) facilitates the activation and nuclear translocation of NF-κB via ILK in ovarian cancer cells.
12-HETE inhibits insulin secretion, reduces metabolic activity and induces cell death in human islets. 12-HETE increases bovine platelet aggregation induced by thrombin and inhibits prostaglandin E1-induced elevation of intracellular cAMP levels. 12-HETE inhibits washed platelet (WP) aggregation.
The neuronal effects of 12-HETE include attenuation of calcium influx and glutamate release as well as inhibition of AMPA receptor (AMPA-R) activation.
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