GW280264X,866924-39-2

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GW280264X

CAS No. : 866924-39-2

MCE 国际站：GW280264X

产品活性：GW280264X 是 ADAM10/TACE (ADAM17) 金属蛋白酶抑制剂。GW280264X 有效阻断 TACE (ADAM17) 和 ADAM10，IC₅₀ 分别为 8.0 nM 和 11.5 nM。ADAM10/17 可调节胶质母细胞瘤起始细胞的免疫原性。

研究领域：Metabolic Enzyme/Protease

作用靶点：MMP

In Vitro: The proliferation of GS-7 cells was significantly reduced upon treatment with GW280264X or ADAM10/17 co-knockdown.

In Vivo: Pharmacological inhibition of ADAM10 and ADAM17 improves functional recovery after spinal cord injury (SCI).

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