Pyrrophenone

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Pyrrophenone

CAS No. : 341973-06-6

MCE 国际站：Pyrrophenone

产品活性：Pyrrophenone 是一种有效且特异性的胞质磷脂酶 A₂α (cPLA₂α) 抑制剂，IC₅₀ 值为 4.2 nM。

研究领域：Metabolic Enzyme/Protease

作用靶点：Phospholipase

In Vitro: Pyrrophenone shows potent inhibition of arachidonic acid release, prostaglandin E₂, thromboxane B₂, and leukotriene B₄ formation in human whole blood.
Pyrrophenone inhibits the production of arachidonic acid (AA) (IC₅₀=24±1.7 nM), PGE₂ (IC₅₀=25±19 nM),, and LTC₄ (IC₅₀=14±6.7 nM),from THP-1 cells stimulated with A23187.
Pyrrophenone inhibits the production of AA (IC₅₀=0.19±0.068 μM), PGE₂ (IC₅₀=0.20±0.047 μM), TXB₂ (IC₅₀=0.16±0.093 μM),and LTB₄ (IC₅₀=0.32±0.24 μM) from human whole blood stimulated with A23187.
Pyrrophenone (0.1-0.5 μM, 48 h) inhibits the growth of PC-PTC3 and PCCl₃ cells.

In Vivo: Pyrrophenone (administered i.p. at 20 mg/kg 30 min before LPS injection.) suppresses bronchoalveolar lavage (BAL) levels of leukotriene B4 (LTB₄) and platelet activating factor (PAF).

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