- ￥1090 - 2730
- Proteintech
- APC-65155
- 2025年10月13日
- FC
- Mouse
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
None
- 亚型：
IgG1, kappa
- 保存条件：
Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.
- 克隆性：
Monoclonal
- 标记物：
APC Fluorescent Dye
- 适应物种：
human
- 保质期：
详见产品包装
- 库存：
充足
- 宿主：
Mouse
- 应用范围：
FC
- 靶点：
CD206
- 抗体英文名：
APC Anti-Human CD206 (15-2)
- 抗体名：
APC Anti-Human CD206 (15-2)
- 规格：
25tests/100tests
| 规格： | 25tests | 产品价格： | ￥1090.0 |
|---|---|---|---|
| 规格： | 100tests | 产品价格： | ￥2730.0 |
经过测试的应用
| Positive FC detected in | GM-CSF treated human PBMCs |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Flow Cytometry (FC) | FC : 5 ul per 10^6 cells in 100 μl suspension |
| This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
APC-65155 targets CD206 in FC applications and shows reactivity with human samples.
| 经测试应用 | FC |
| 文献引用应用 | FC |
| 经测试反应性 | human |
| 文献引用反应性 | human |
| 免疫原 |
fusion protein |
| 宿主/亚型 | Mouse / IgG1, kappa |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | mannose receptor, C type 1 |
| 别名 | 15-2, CLEC13D, CLEC13DL, C-type lectin domain family 13 member D, C-type lectin domain family 13 member D-like |
| 计算分子量 | 166 kDa |
| GenBank蛋白编号 | NM_002438 |
| 基因名称 | CD206 |
| Gene ID (NCBI) | 4360 |
| RRID | AB_2918930 |
| 偶联类型 | APC Fluorescent Dye |
| 最大激发/发射波长 | 650 nm / 660 nm |
| 形式 | Liquid |
| 纯化方式 | The purified antibody is conjugated with allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography. |
| UNIPROT ID | P22897 |
| 储存缓冲液 | PBS with 0.09% sodium azide and 0.5% BSA, pH 7.3. |
| 储存条件 | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
背景介绍
CD206, also named as MMR, CLEC13D and MRC1, is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. CD206 has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. CD206 is a 170 kDa transmembrane protein which contains 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail. It is expressed on most tissue macrophages, in vitro derived dendritic cells, lymphatic and sinusoidal endothelia.
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文献和实验| Species | Application | Title |
|---|---|---|
| FC | Int J Mol Sci C-X-C Motif Chemokine 3 Promotes the Inflammatory Response of Microglia after Escherichia coli-Induced MeningitisAuthors - Xinyi Qu | |
| human | FC | Cell Mol Life Sci Tumor-associated macrophage-derived exosomal miR21-5p promotes tumor angiogenesis by regulating YAP1/HIF-1α axis in head and neck squamous cell carcinomaAuthors - Quan Yan |
| human | FC | Front Immunol Identification of a distinct cluster of GDF15high macrophages induced by in vitro differentiation exhibiting anti-inflammatory activitiesAuthors - Chaochao Dai |
图2 APC 5＇末端的扩增。用对应APC mRNA的位置5846的GSP反转录1mg Hela总RNA得到APC mRNA。cDNA被纯化、加尾，和用对应位置1797（A带）和位置1632（B带）的引物和AAP一起，用ELONGASE酶混合物来扩增（94℃ 30s，接着35个循环的94℃ 15 s，55℃ 30 s，68℃ 5 min）。初步PCR用TE缓冲液稀释100倍，取1ml用引物APC－1632（A带）或引物APC－1242（B带）和AUAP分别重新扩增（30个循环），每个PCR
内皮细胞是一个典型的例子。该细胞广泛分布于血管和淋巴组织。小鼠中经IFN-7等诱导后，此类细胞可表达MHCⅡ类分子和协同刺激分子；在人类，两种分于皆呈组成性表达。而且血管内皮细胞在接触抗原的部位，也可参与激活抗原特异性T细胞。 另外，下面将要提到，抗原提呈是分成内源性抗原和外源性抗原两种不同途径的。凡能表达MHC I类分子的有核细胞，皆可实施对内源性抗原的加工和提呈，并激活CD8CTL。在这个意义上，所有有核细胞又都可以作为非专职APC发挥作用。或者，如前所说，能够激活CTL
专职抗原提呈细胞（ APC ） 抗原提呈细胞(APC)是指具有加工和提呈抗原能力的细胞。所有有核细胞都具有降解胞质内蛋白的能力，而且都表达MHC I类分子，所以有核细胞一旦表达非己抗原时，例如受病毒感染或发生癌变时，都能成为APC，向T细胞提呈抗原。但通常把通过MHC I类分子向CD8T细胞提呈抗原的细胞称为靶细胞，而只把表达MHCⅡ类分子并能向CD4T细胞提呈抗原的细胞称为APC。 通常情况下，如不加说明，APC即指专职APC，不包括非专职APC。专职
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