TGM2 单克隆抗体 68006-1-Ig
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TGM2 单克隆抗体 68006-1-Ig

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  • ￥1350 - 3000
  • Proteintech已认证
  • 68006-1-Ig
  • 2025年10月13日
  • WB, IHC, IF/ICC, FC (Intra), ELISA
  • Mouse
  • human
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 免疫原：

      Recombinant human TGM2 protein

    • 亚型：

      IgG2a

    • 保存条件：

      Store at -20°C. Stable for one year after shipment.

    • 克隆性：

      Monoclonal

    • 标记物：

      Unconjugated

    • 适应物种：

      human

    • 保质期：

      详见产品包装

    • 库存：

      充足

    • 宿主：

      Mouse

    • 应用范围：

      WB, IHC, IF/ICC, FC (Intra), ELISA

    • 靶点：

      TGM2

    • 抗体英文名：

      TGM2 Monoclonal antibody

    • 抗体名：

      TGM2 Monoclonal antibody

    • 规格：

      50ul/100ul/150ul

    规格：50ul产品价格：￥1350.0
    规格：100ul产品价格：￥2200.0
    规格：150ul产品价格：￥3000.0

    经过测试的应用

    Positive WB detected inHeLa cells, human placenta tissue, HUVEC cells, HepG2 cells, K-562 cells
    Positive IHC detected inhuman liver cancer tissue
    Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
    Positive IF/ICC detected inA549 cells
    Positive FC (Intra) detected inHeLa cells
    Planning an IHC experiment? We recommend our IHCeasy TGM2 Ready-To-Use IHC Kit. TGM2 primary antibody included.
    Planning an IF experiment? We recommend our CoraLite® Plus 488 conjugated versions of this antibody.

    推荐稀释比

    应用推荐稀释比
    Western Blot (WB)WB : 1:5000-1:50000
    Immunohistochemistry (IHC)IHC : 1:2000-1:8000
    Immunofluorescence (IF)/ICCIF/ICC : 1:400-1:1600
    Flow Cytometry (FC) (INTRA)FC (INTRA) : 0.40 ug per 10^6 cells in a 100 µl suspension
    It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
    Sample-dependent, Check data in validation data gallery.

    产品信息

    68006-1-Ig targets TGM2 in WB, IHC, IF/ICC, FC (Intra), ELISA applications and shows reactivity with human samples.

    经测试应用 WB, IHC, IF/ICC, FC (Intra), ELISA
    文献引用应用WB, IHC, IF
    经测试反应性 human
    文献引用反应性human, mouse, hamster
    免疫原

    CatNo: Ag7462

    Product name: Recombinant human TGM2 protein

    Source: e coli.-derived, PET28a

    Tag: 6*His

    Domain: 1-349 aa of BC003551

    Sequence: MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFSVVTGPAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTLSLQLTTPANAPIGLYRLSLEASTGYQGSSFVLGHFILLFNAWCPADAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNIPWNFGQFEDGILDICLILLDVNPKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGRWDNNYGDGVSPMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTNYNSAHDQNSNLLIEYFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQP
    宿主/亚型 Mouse / IgG2a
    抗体类别 Monoclonal
    产品类型 Antibody
    全称 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
    别名 2D4C11, Erythrocyte transglutaminase, TG(C), TG2, TGase 2
    计算分子量 77 kDa
    观测分子量80 kDa
    GenBank蛋白编号BC003551
    基因名称 TGM2
    Gene ID (NCBI) 7052
    ENSEMBL Gene IDENSG00000198959
    RRIDAB_2918753
    偶联类型 Unconjugated
    形式Liquid
    纯化方式Protein A purification
    UNIPROT IDP21980
    储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
    储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

    背景介绍

    Transglutaminase 2 (TGM2) is a ubiquitous and multifunctional calcium-dependent enzyme belonging to the transglutaminase family. It is best known for its canonical activity of catalyzing the cross-linking of proteins by forming stable ε-(γ-glutamyl)lysine isopeptide bonds, which contributes to extracellular matrix stabilization and wound healing. Beyond this, TGM2 exhibits GTPase activity, allowing it to function as a signaling G-protein in intracellular processes. It is implicated in a wide range of physiological functions, including cell adhesion, proliferation, and apoptosis, as well as pathological conditions such as celiac disease, fibrosis, neurodegenerative disorders, and cancer metastasis, where its dysregulated expression often contributes to disease progression.

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    图标文献和实验
    该产品被引用文献
    SpeciesApplicationTitle
    humanIF

    Biomaterials

    Tumor-specific nitric oxide generator to amplify peroxynitrite based on highly penetrable nanoparticles for metastasis inhibition and enhanced cancer therapy.

    Authors - Menghao Shi
    mouseWB,IHC

    Transl Res

    Counteracting TGM2 by a Fibroin peptide ameliorated Adriamycin-induced nephropathy via regulation of lipid metabolism through PANX1-PPAR α/PANK1 pathway

    Authors - Shan-Shan Li

    F1000Res

    A guide to selecting high-performing antibodies for Protein-glutamine gamma-glutamyltransferase 2 (TGM2) for use in western blot, immunoprecipitation and immunofluorescence

    Authors - Riham Ayoubi
    hamsterWB

    ACS Synth Biol

    Overexpression of Tgm2 in Chinese Hamster Ovary Cells Enhances Recombinant Monoclonal Antibody Expression and Promotes Cell Proliferation through Reduction of Apoptosis

    Authors - Hui-Jie Zhang
    • KD Validated
    图标技术资料

    暂无技术资料 索取技术资料

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    TGM2 单克隆抗体 68006-1-Ig
    ￥1350 - 3000