- ￥1350 - 3000
- Proteintech
- 14948-1-AP
- 2025年10月13日
- WB, IHC, IP, ELISA
- Rabbit
- human, mouse, rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant human LMOD3 protein
- 亚型：
IgG
- 保存条件：
Store at -20°C. Stable for one year after shipment.
- 克隆性：
Polyclonal
- 标记物：
Unconjugated
- 适应物种：
human, mouse, rat
- 保质期：
详见产品包装
- 库存：
充足
- 宿主：
Rabbit
- 应用范围：
WB, IHC, IP, ELISA
- 靶点：
LMOD3
- 抗体英文名：
LMOD3 Polyclonal antibody
- 抗体名：
LMOD3 Polyclonal antibody
- 规格：
50ul/100ul/150ul
| 规格： | 50ul | 产品价格： | ￥1350.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥2200.0 |
| 规格： | 150ul | 产品价格： | ￥3000.0 |
经过测试的应用
| Positive WB detected in | mouse skeletal muscle tissue, mouse heart tissue, rat skeletal muscle tissue |
| Positive IP detected in | mouse skeletal muscle tissue |
| Positive IHC detected in | mouse skeletal muscle tissue, human heart tissue, human skeletal muscle tissue, mouse heart tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:2000-1:10000 |
| Immunoprecipitation (IP) | IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate |
| Immunohistochemistry (IHC) | IHC : 1:500-1:2000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
14948-1-AP targets LMOD3 in WB, IHC, IF, IP, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, IHC, IP, ELISA |
| 文献引用应用 | WB, IHC, IF |
| 经测试反应性 | human, mouse, rat |
| 文献引用反应性 | human, mouse, zebrafish, xenopus |
| 免疫原 |
CatNo: Ag6758 Product name: Recombinant human LMOD3 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-236 aa of BC039202 Sequence: MSEHSRNSDQEELDEEINEDEILANLSAEELKELQSEMEVMAPDPSLPVGMIQKDQTDKPPTGNFNHKSLVDYMYWEKASRRMLEEERVPVTFVKSEEKTQEEHEEIEKRNKNMAQYLKEKLNNEIVANKRESKGSSNIQETDEEDEEEEDDDDDDEGEDDGEESEETNREEEGKAKEQIRNCENNCQQVTDKAFKEQRDRPEAQEKKKKKISQGKIIFRKNNVRAQQKFRSRRTR |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | leiomodin 3 (fetal) |
| 别名 | Leiomodin-3 |
| 计算分子量 | 65 kDa |
| 观测分子量 | 65-70 kDa |
| GenBank蛋白编号 | BC039202 |
| 基因名称 | LMOD3 |
| Gene ID (NCBI) | 56203 |
| RRID | AB_2136690 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q0VAK6 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
The gene encoding LMOD3 has not been characterized so far and very limited information of its function has been reported. Nanda et al. found that the expression of mouse LMOD3 mRNA is restricted largely to cardiac and skeletal muscle through RT-PCR analysis (PMID: 22157009). Two isoforms of LMOD3 may exist due to the alternative splicing, whose molecular weights are predicted as 65 kDa and 40 kDa, respectively (Uniprot). This antibody was raised against the N-terminal region of human LMOD3. It detects a double bands around 80 kDa and 65 kDa in heart and skeletal muscle lysates. The reason causing the discrepancy between the predicted and observed molecular weight is not clear.
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文献和实验| Species | Application | Title |
|---|---|---|
| mouse | WB | Sci Adv Nebulin and Lmod2 are critical for specifying thin-filament length in skeletal muscle.Authors - Balázs Kiss |
| zebrafish,human | WB,IF | J Clin Invest Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.Authors - Michaela Yuen |
| mouse | WB | J Clin Invest Severe myopathy in mice lacking the MEF2/SRF-dependent gene leiomodin-3.Authors - Bercin K Cenik
|
| zebrafish | WB,IF | J Clin Invest Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.Authors - Michaela Yuen |
| human | WB | J Clin Invest KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy.Authors - Ankit Garg |
| mouse | WB | Proc Natl Acad Sci U S A HSPB7 is indispensable for heart development by modulating actin filament assembly.Authors - Tongbin Wu |
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