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Mono-Me/thyl-P53 (Lys370) Monoclonal Antibody_货号:E-AB-50004_修饰性抗体
Mono-Me/thyl-P53 (Lys370) Monoclonal Antibody
IHC-p
Mouse
Human;Mouse;Rat
12个月
E-AB-50004
科研级别
999
武汉伊莱瑞特生物科技股/份有限公司
Unconjugated
Monoclonal
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
液体
IgG
120μL/60μL/20μL
规格: | 120μL | 产品价格: | ¥2415.0 |
---|---|---|---|
规格: | 60μL | 产品价格: | ¥1510.0 |
规格: | 20μL | 产品价格: | ¥630.0 |
Verified Samples |
Verified Samples in IHC:Human lung carcinoma
|
Dilution |
IHC 1:50-1:200
|
Clonality |
Monoclonal
|
Isotype |
IgG
|
Immunogen |
Synthetic Peptide
|
Abbre |
P53 (Mono Me/thyl Lys370)
|
Synonyms |
Antigen NY-CO-13;BCC7;Cellular tumor antigen p53;FLJ92943;LFS1;Mutant tumor protein 53;p53;p53 tumor suppressor;P53;Phosphoprotein p53;Tp53;Transformation related protein 53;TRP53;Tumor protein 53;Tumor protein p53;Tumor suppressor p53抗体
|
Swissprot |
P04637
|
Cellular Localization |
Cytoplasm; Cytoplasm. Nucleus. Nucleus>PML body. Endoplasmic reticulum. Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2; Nucleus. Cytoplasm. Localized in both nucleus and cytoplasm in most cells. In some cells, forms foci in the nucleus that are different from nucleoli; Nucleus. Cytoplasm. Localized in the nucleus in most cells but found in the cytoplasm in some cells; Nucleus. Cytoplasm. Localized mainly in the nucleus with minor staining in the cytoplasm; Nucleus. Cytoplasm. Predominantly nuclear but localizes to the cytoplasm when expressed with isoform 4 and Nucleus. Cytoplasm. Predominantly nuclear but translocates to the cytoplasm following cell stress.
|
Tissue Specificity |
Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord and fetal liver. Isoform 3 is expressed in most normal tissues but is not detected in lung, spleen, testis, fetal brain, spinal cord and fetal liver. Isoform 7 is expressed in most normal tissues but is not detected in prostate, uterus, skeletal muscle and breast. Isoform 8 is detected only in colon, bone marrow, testis, fetal brain and intestine. Isoform 9 is expressed in most normal tissues but is not detected in brain, heart, lung, fetal liver, salivary gland, breast or intestine.
|
Concentration |
1 mg/mL
|
Storage |
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
|
Buffer |
PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
|
Purification Method |
Protein A purification
|
Research Areas |
Cancer; Cell Biology; Epigenetics and Nuclear Signaling
|
Clone No. |
Clone:4A1
|
Conjugation |
Unconjugated
|
Background |
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.
|
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