PNRC2 多克隆抗体

免疫组织化学（IHC）已验证样本:Human cervical cancer,Human colorectal cancer

IHC 1:50-1:300, ELISA 1:5000-1:10000

Polyclonal

IgG

Fusion protein of human PNRC2

PNRC2

0610011E17Rik;D4Bwg0593e;FLJ20312;MGC11707;MGC93828;MGC99541;OTTMUSP00000010360;OTTMUSP00000010366;pnrc2;PNRC2;Proline rich nuclear receptor coactivator 2;Proline-rich nuclear receptor coactivator 2;RP11-4M23.5;RP23-161N17.3抗体

Q9NPJ4

Nucleus. Cytoplasm>P-body.

0.84 mg/mL

在-20℃下储存有效期为12个月。 避免冻融循环。

PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Antigen affinity purification

Epigenetics and Nuclear Signaling

Unconjugated

Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed:19150429). Required for UPF1/RENT1 localization to the P-body (PubMed:19150429). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Also acts as a nuclear receptor coactivator (PubMed:11574675). May play a role in controlling the energy balance between energy 储存方法 and energy expenditure (By similarity).