PPM1D 多克隆抗体

免疫组织化学（IHC）已验证样本:Human brain,Human ovarian cancer

IHC 1:50-1:300, ELISA 1:2000-1:5000

Polyclonal

IgG

Fusion protein of human PPM1D

PPM1D

EC 3.1.3.16;p53 induced protein phosphatase 1;p53-induced protein phosphatase 1;PP2C delta;PP2C-delta;PP2CD;Ppm1d;PPM1D;Protein phosphatase 1D;protein phosphatase 1D magnesium-dependent delta isoform ;Protein phosphatase 2C delta isoform;Protein phosphatase 2C isoform delta;Protein phosphatase magnesium dependent 1 delta;Protein phosphatase magnesium-dependent 1 delta;Protein phosphatase Mg2+/Mn2+ dependent 1D;Protein phosphatase Wip1;Wild type p53 induced phosphatase 1;WIP 1;WIP1抗体

O15297

0.5 mg/mL

在-20℃下储存有效期为12个月。 避免冻融循环。

PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Antigen affinity purification

Cancer; Signal transduction

Unconjugated

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.