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CORO2B Polyclonal Antibody_货号:E-AB-19746_多克隆抗体
CORO2B Polyclonal Antibody
WB;IHC;ELISA
Rabbit
Human; Mouse
12个月
E-AB-19746
科研级别
999
武汉伊莱瑞特生物科技股份有限公司
Unconjugated
Polyclonal
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
液体
IgG
200μL/120μL/60μL/20μL
规格: | 200μL | 产品价格: | ¥2365.0 |
---|---|---|---|
规格: | 120μL | 产品价格: | ¥1640.0 |
规格: | 60μL | 产品价格: | ¥1010.0 |
规格: | 20μL | 产品价格: | ¥420.0 |
Verified Samples |
Verified Samples in WB:Mouse brain,NIH/3T3
Verified Samples in IHC:Human liver cancer |
Dilution |
WB 1:1000-1:5000, IHC 1:40-1:200, ELISA 1:5000-1:10000
|
Clonality |
Polyclonal
|
Isotype |
IgG
|
Immunogen |
Synthetic peptide of human CORO2B
|
Abbre |
CORO2B
|
Synonyms |
Actin binding protein;Clipin-C;CLIPINC;COR2B;CORO2B;Coronin actin binding protein 2B;Coronin;Coronin-2B;Coronin-like protein C;Protein FC96抗体
|
Swissprot |
Q9UQ03
|
Calculated MW |
55 kDa
|
Observed MW |
Refer to figures
|
Cellular Localization |
Cytoplasm>cytoskeleton.
|
Concentration |
1.5 mg/mL
|
Storage |
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
|
Buffer |
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
|
Purification Method |
Antigen affinity purification
|
Research Areas |
Signal transduction
|
Conjugation |
Unconjugated
|
Background |
Coronins are a family of WD repeat-containing, actin-binding proteins that localize to submembraneous areas and regulate cell motility and cytoskeletal rearrangement. Coronin 1A (CORO1A, CLIPINA, CLABP, TACO, p57) can form coiled coil-mediated homotrimeric complexes that influence early phagosome formation. PKC-dependent phosphorylation of Coronin 1B (CORO1B) at Serine 2 regulates leading edge dynamics and cell motility in fibroblasts through interactions with Arp2/3 complex. Coronin 1C (CORO1C, Coronin 3, HCRNN4) is abundant in differentiating Neuro-2a cells, PC-12 cells and primary oligodendrocytes, where it is thought to influence neuron morphogenesis and migration. Coronin 2A (CORO2A, CLIPINB, IR10, WDR2) is a component of the approximately 1.5-2 megadalton N-CoR (nuclear receptor corepressor) complex of 10-12 proteins, which recruits HDACs to generate repressive chromatin. Coronin 7 (CORO7, CRN7) localizes to the Golgi membrane and influences the organization of intracellular membrane compartments and vesicular trafficking. Coronin 2B (CORO2B, CLIPINC) and Coronin 6 (CORO6) are similar to other members of this family, since they possess a conserved basic N-terminal motif and 3-10 WD repeats clustered in one to two core domains.
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