ATRX 多克隆抗体

免疫组织化学（IHC）已验证样本:Human thyroid cancer,Human ovarian cancer

IHC 1:30-1:150, ELISA 1:5000-1:10000

Polyclonal

IgG

Synthetic peptide of human ATRX

ATRX

Alpha thalassemia/mental retardation syndrome X linked homolog;ATP dependent helicase ATRX;ATP-dependent helicase ATRX;ATR2;Atrx;ATRX;DNA dependent ATPase and helicase;Helicase 2; X linked;MGC2094;MRXHF1;RAD54;RAD54L;SFM1;SHS;Transcriptional regulator ATRX;X linked helicase II;X linked nuclear protein;X-linked helicase II;X-linked nuclear protein;XH2;XNP;Znf HX;Znf-HX抗体

P46100

Nucleus. Chromosome, telomere. Nucleus, PML body. Associated with pericentromeric heterochromatin during interphase and mitosis, probably by interacting with CBX5/HP1 alpha. Colocalizes with histone H3.3, DAXX, HIRA and ASF1A at PML-nuclear bodies. Colocalizes with cohesin (SMC1 and SMC3) and MECP2 at the maternal H19 ICR (By similarity).

0.7 mg/mL

在-20℃下储存有效期为12个月。 避免冻融循环。

PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Antigen affinity purification

Unconjugated

The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.