HIPK3 多克隆抗体

免疫组织化学（IHC）已验证样本:Human colorectal cancer

IHC 1:50-1:300, ELISA 1:5000-1:10000

Polyclonal

IgG

Synthetic peptide of human HIPK3

HIPK3

Androgen receptor interacting nuclear protein kinase;Androgen receptor-interacting nuclear protein kinase;ANPK;DYRK6;Fas interacting serine/threonine protein kinase;Fas-interacting serine/threonine-protein kinase;FIST;FIST3;Hipk3;HIPK3;homeodomain interacting protein kinase 3;Homeodomain-interacting protein kinase 3;Homolog of protein kinase YAK1;PKY;RP24 297H17.5;YAK1抗体

Q9H422

Cytoplasm. Nucleus.

0.6 mg/mL

在-20℃下储存有效期为12个月。 避免冻融循环。

PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Antigen affinity purification

Cancer; Cell Biology; Epigenetics and Nuclear Signaling; Signal transduction

Unconjugated

Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).