CCNE1 多克隆抗体

免疫组织化学（IHC）已验证样本:Human tonsil,Human cervical cancer

IHC 1:30-1:150, ELISA 1:5000-1:10000

Polyclonal

IgG

Synthetic peptide of human CCNE1

CCNE1

CCNE;Ccne1;CCNE1;cyclin E variant ex5del;cyclin E variant ex7del;Cyclin E1;Cyclin Es;Cyclin Et;CyclinE;G1/S specific cyclin E;G1/S-specific cyclin-E1抗体

P24864

Nucleus.

0.9 mg/mL

在-20℃下储存有效期为12个月。 避免冻融循环。

PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Antigen affinity purification

Cancer; Cell Biology; Epigenetics and Nuclear Signaling

Unconjugated

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB.