SRPK2 多克隆抗体

免疫组织化学（IHC）已验证样本:Human thyroid cancer

IHC 1:100-1:300, ELISA 1:5000-1:10000

Polyclonal

IgG

Fusion protein of human SRPK2

SRPK2

Human serine kinase SRPK2 mRNA; complete cds;Serine kinase SRPK2;Serine/arginine rich protein specific kinase 2;Serine/arginine-rich protein-specific kinase 2;Serine/threonine protein kinase SRPK2 ;SFRS protein kinase 2;SFRSK2 ;SR protein specific kinase 2;SR-protein-specific kinase 2;SRPK2;SRPK2;SRSF protein kinase 2 C-terminal抗体

P78362

Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm. KAT5/TIP60 inhibits its nuclear translocation. Phosphorylation at Thr-492 by PKB/AKT1 promotes nuclear translocation.

1.56 mg/mL

在-20℃下储存有效期为12个月。 避免冻融循环。

PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Antigen affinity purification

Cancer; Cell Biology; Epigenetics and Nuclear Signaling

Unconjugated

Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.