MICA 多克隆抗体

免疫组织化学（IHC）已验证样本:Human liver cancer

IHC 1:50-1:200, ELISA 1:5000-1:10000

Polyclonal

IgG

Fusion protein of human MICA

MICA

HLA class I antigen;FLJ36918;FLJ60820;MGC111087;MGC21250;MHC class I chain related gene A protein;MHC class I chain related protein A;MHC class I chain related protein A HLA B HLA C;MHC class I polypeptide related sequence A;MHC class I polypeptide-related sequence A;MHC class I related protein;MIC A;MIC-A;micA;MICA;OTTHUMP00000029088;OTTHUMP00000044528;OTTHUMP00000165170;OTTHUMP00000165172;PERB11.1;Stress inducible class I homolog抗体

Q29983

Cell membrane. Cytoplasm. Expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K protein which causes retention in the endoplasmic reticulum.

0.6 mg/mL

在-20℃下储存有效期为12个月。 避免冻融循环。

PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Antigen affinity purification

Cancer; Immunology

Unconjugated

This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.