KIAA0556 多克隆抗体

免疫组织化学（IHC）已验证样本:Human liver cancer

IHC 1:50-1:200, ELISA 1:5000-1:10000

Polyclonal

IgG

Synthetic peptide of human KIAA0556

KIAA0556

K0556;KIAA0556;Uncharacterized protein KIAA0556抗体

O60303

0.96 mg/mL

在-20℃下储存有效期为12个月。 避免冻融循环。

PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Antigen affinity purification

Cell Biology

Unconjugated

This gene encodes a novel, evolutionarily conserved, ciliary protein. In human hTERT-RPE1 cells, the protein is found at the base of cilia, decorating the ciliary axoneme, and enriched at the ciliary tip. The protein binds to microtubules in vitro and regulates their stability when it is overexpressed. A null mutation in this gene has been associated with Joubert syndrome, a recessive disorder that is characterized by a distinctive mid-hindbrain and cerebellar malformation and is also often associated with wider ciliopathy symptoms. Consistently, in a serum-starvation ciliogenesis assay, human fibroblast cells derived from patients with the mutation display a reduced number of ciliated cells with abnormally long cilia.