HLA-DRB3 多克隆抗体

免疫组织化学（IHC）已验证样本:Human cervical cancer

IHC 1:20-1:100, ELISA 1:5000-1:10000

Polyclonal

IgG

Synthetic peptide of human HLA-DRB3

HLA-DRB3

DR beta 3 chain;DR7;DRB3;HLA class II histocompatibility antigen;HLA class II histocompatibility antigen DR beta 3 chain;HLA class II histocompatibility antigen DRB1 7 beta chain;HLA DR3B;HLA-DRB3;Human leucocyte antigen DRB3;Major histocompatibility complex class II DR beta 3;MGC117330;MHC class II antigen DR beta 3 chain;MHC class II antigen DRB3;MHC class II HLA DR beta 3 chain抗体

P79483

Cell membrane. Endoplasmic reticulum membrane. Golgi apparatus>trans-Golgi network membrane. Endosome membrane. Lysosome membrane. Late endosome membrane. The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.

1.44 mg/mL

在-20℃下储存有效期为12个月。 避免冻融循环。

PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Antigen affinity purification

Immunology

Unconjugated

HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.